The Effect of Pagoda Flower Extract (Clerodendrum Paniculatum L) on Pancreatic Function and Histopathological Features of the Pancreas of Male Wistar White Rats Infected with Leptospira Bacteria

Abstract

This study was conducted to test the effect of pagoda flower extract (Clerodendrum
paniculatum L.) on pancreatic function and histopathological picture of the pancreas of male
Wistar white rats infected with Leptospira interrogans bacteria. Based on the difference in the
average lipase levels of treatment group 3, namely rats infected with bacteria and given
pagoda flowers at a dose of 200mg/KgBW, had the greatest decrease in lipase levels and
approached the control group. P3 group after being infected with bacteria amylase- lipase
level 68.45U/L- 42.06U/L and after being given pagoda flower extract with a dose of
200mg/KgBB, the amylase-lipase level became 58.75U/L-22.71U/L. There was no necrosis
for the histopathological picture of treatment group 3 (P3). However, there was still a little
leukocyte infiltration in the pancreatic cells, so this treatment group got a score of 0 without
necrosis of pancreatic cells. Thus, it can be concluded that pagoda flower extract affects the
pancreatic function of rats infected with leptospira bacteria. The Kolmogorov-Smirnov data
analysis p>0.05 is 0.200, so the data is usually distributed.