The Effect of Pagoda Flower Extract (Clerodendrum Paniculatum L) on Collagenization and Histopathological Features of Skin Tissue in the Healing Process of Dermapen Wounds in Male Wistar White Rats

Abstract

This study was conducted to test the effect of pagoda flower extract (Clerodendrum
Paniculatum L) on collagenization and histopathological features of skin tissue in the healing
process of wounds from dermapen in male white Wistar rats. The treatment was given in the
form of 10%, 15%, and 20% cream on the healing process of wounds from dermapen.
Phytochemical tests found that pagoda flowers positively contained active compounds such
as alkaloids, flavonoids, saponins, and tannins. From the observations of wound healing, the
control group had 71.5% of wounds closed. In treatment group 1, the percentage of wound
healing was 100% on the 13th day, and in treatment groups 2 and 3 on the 12th day. In
histopathological observations, the collagen density of the wound was already tight in
treatment groups 2 and 3, with 15% and 20% pagoda flower cream extracts. So, pagoda
flower extract is effective in healing wounds from dermapen. Kolmogorov-Smirnov test
normality test The results of wound healing data in each group are normally distributed with
a significance value of 0.200> 0.05 in all test groups.