The Effect Of Giving Cloves Extract (Syzygium Aromaticum) On Kidney Function And Kidney Histopathology Of Male Wistar White Rats Infected With Staphylococcus Aureus Bacteria

Abstract

This research aims to test and analyze the effectiveness of administering clove extract
(Syzygium aromaticum) on the kidney function of male white rats (Rattus norvegicus) of
the Wistar strain infected with Staphylococcus aureus and how the histopathological
picture is. The research sample, namely 24 male rats (Rattus norvegicus) of the Wistar
strain were divided into 4 groups and received different treatments. The treatment group
was given an infection with a suspension of Staphylococcus aureus bacteria and clove
extract (Syzygium aromaticum) with different doses of 150 mg/KgBW, 350 mg/KgBW,
and 450 mg/KgBW. The results of the observation showed that clove extract contains
secondary metabolites in the form of saponins, tannins, flavonoids, and steroids that help
repair damaged kidney cells and decrease kidney function due to Staphylococcus aureus
bacterial infection. The active compound that plays the most role in improving kidney
function is flavonoids. Administration of clove extract at a dose of 450 mg/KgBW is
effective in improving kidney function in white rats (Rattus norvegicus) of the Wistar
strain infected with Staphylococcus aureus. This improvement can be seen through the
levels of urea, creatinine, and the histological structure of the kidneys that have
improved. The results of histopathological observations of kidney tissue in treatment
group 3, namely clove extract with a dose of 450 mg/KgBW, experienced the most
significant improvement and approached the control group compared to the other groups.