The Effect of Pagoda Flower Extract (Clerodendrum Paniculatum L.) on Pancreatic Function and Histopathological Features of the Pancreas of Male Wistar White Rats Infected with Leptospira Bacteria

Abstract

This study was conducted to test the effect of pagoda flower extract (Clerodendrum paniculatum L.) on pancreatic function and histopathological picture of the pancreas of male Wistar white rats infected with Leptospira interrogans bacteria. Based on the difference in the average lipase levels of treatment group 3, namely rats infected with bacteria and given pagoda flowers at a dose of 200mg/KgBW, had the greatest decrease in lipase levels and approached the control group. P3 group after being infected with bacteria amylase- lipase level 68.45U/L- 42.06U/L and after being given pagoda flower extract with a dose of 200mg/KgBB, the amylase-lipase level became 58.75U/L-22.71U/L. There was no necrosis for the histopathological picture of treatment group 3 (P3). However, there was still a little leukocyte infiltration in the pancreatic cells, so this treatment group got a score of 0 without necrosis of pancreatic cells. Thus, it can be concluded that pagoda flower extract affects the pancreatic function of rats infected with leptospira bacteria. The Kolmogorov-Smirnov data analysis p>0.05 is 0.200, so the data is usually distributed.