HASIL SEMINAR NASIONAL UNPRI

Analysis Of Factors Related To The Performance Of Employees At The Siulak Deras And Simpang Tutup Community Health Center, Gunung Kerinci District, Kerinci Regency

Elvan Tripolta — 2025-03-26

The aim of the research is to analyze factors related to the performance of employees at the Siulak Deras and Simpang Clos Health Centers, Gunung Kerinci District, Kerinci Regency. The research technique used is the Chi-Square analysis test, with an analytical method with a Cross-Sectional Study design. The research population was employees of the Siulak Deras and Simpang Kunci health centers. The sampling technique used total sampling, namely all employees who worked at the Siulak Deras and Simpang Kunci health centers were 125 employees.

The research showed that the performance of the Siulak Deras and Simpang Kunci Health Centers was good. Variables that have a relationship with employee performance are work quality, work quantity, and timeliness as evidenced by the results of each statistical test with a significance level of p-value = 0.000 (P <0.05). Accompanied by the effectiveness variable with a p-value = 0.002, independence has a p-value = 0.023, and workload has a p-value = 0.004. It is recommended that employees to maintain their work enthusiasm, especially in carrying out their duties responsibly, namely by completing their tasks from start to finish.

ANALYSIS OF THE EVALUATION OF THE IMPLEMENTATION OF THE BLOOD SUPPLYING TABLET PROGRAM (TTD) FOR ADOLESCENT FEMALES AS AN EFFORT TO PREVENT ANEMIA AT SMKN 2 KERINCI DISTRICT

Nilva Elvia — 2025-03-26

One of the Ministry of Health's activities to overcome iron deficiency in adolescent girls is implementing a program to provide iron tablets to teenage girls with a target of 52%. This study aims to analyze the evaluation of the program for the implementation of the Blood Supplement Tablet (TTD) Programme for adolescent girls as an attempt to prevent anemia at SMKN 2. This research is a descriptive survey research. The sampling technique is purposive sampling. The study's findings by using qualitative data were processed using the content analysis method including input, process, and output. Discrepancies are occurring in the input aspects of facilities and infrastructure. In the process aspect, nonconformities appeared in the distribution, monitoring, recording, and reporting aspects. In the output aspect, mismatches occurred in the target accuracy, timing, and distribution. In this research, there are still discrepancies in input, process, and output aspects in implementing the TTD program in the working area of the Kerinci District Health Service.

EVALUATION OF DRUG MANAGEMENT AT THE PHARMACY INSTALLATION UPTD OF KERINCI DISTRICT

Rima Fitri — 2025-03-26

This research aims to analyze the evaluation of drug management at the Kerinci Regency Pharmacy Installation UPTD. The research method is qualitative. Data was obtained through in-depth interviews with community health center drug managers, IFK drug managers, and heads of the pharmacy and medical equipment sections of the Kerinci District Health Service. Data analysis was carried out using descriptive methods. The research results showed that in 2023 there were several empty medicines in the Pharmacy Installations and Community Health Centers within the scope of the Kerinci District Health Service. Furthermore, the planning process had been carried out by the Integrated Medicine Planning Team but, it was not yet optimal, the medicine procurement process had used the e-catalog method, and storage had not yet been completed. everything is alphabetical. Drug storage facilities and infrastructure were inadequate, the Pharmacy Installation room was found to be leaked, and there was an excessive accumulation of drug boxes at the Puskesmas. Drug distribution should be carried out by the Pharmaceutical Installation, not by the Puskesmas themselves. Recording and reporting are still manual, so there are often discrepancies between the amount of medicine on the stock card and the physical amount. Recording and reporting are still manual, so there are often discrepancies between the amount of the medicine on the stock card and the physical quantity. The general conclusion is that drug management at the Kerinci District Health Service Pharmacy Installation is still not running by the Indonesian Ministry of Health (2016). The Kerinci District Health Service can realize plans to expand drug storage space, increase human resources, facilities, and infrastructure, and hold training programs, integrated drug management applications, and seminars on drug management for both Health Service pharmacy staff and at community health centers.

Analysis Of The Relationship Between Environmental Health Factors And The Incidence Of Stunting In Toddlers In The Working Area Of Kersik Tuo Public Health Center, Kayu Aro District, Kerinci Regency

Emiliya - — 2025-03-26

Environmental health from the aspect of poor sanitation and hygiene will trigger digestive disorders which impact nutrition for growth and turn into the body's resistance to infection, thereby risking stunting in toddlers. This study aims to determine the relationship between environmental health factors and the incidence of stunting in toddlers. The research design uses observational analytics with a cross sectional approach. The total sample was 106 toddlers. The sampling technique for this research is purposive sampling using univariate analysis and bivariate analysis with the chi square test. There is a significant relationship between drinking water sources (p=0.012), physical quality of drinking water (p=0.000), latrine ownership (p=0.013), waste management (p=0.001), waste management (p= 0.017) and hand washing habits (p=0.000) on the incidence of stunting. Drinking water treatment (p=0.432) does not have a significant relationship with the incidence of stunting in the Kersik Tuo Health Center area, Kayu Aro District, Kerinci Regency. It is recommended that health educational workers provide outreach with practical and effective methods related to sanitation and hygiene so that the public can understand the importance of maintaining a healthy environment which has an impact on stunting.

Analysis Of Factors Influencing The Utilization Of Integrated Counseling Posts For Non-Communicable Diseases (Posbindu PTM) In Work Area Siulak Deras Public Health Center, Mount Kerinci District, Kerinci Regency

Syariful Hijri — 2025-03-26

This study aims to analyze the factors that influence the use of the Integrated Development Post for Non-Communicable Diseases (Posbindu PTM) in Siulak Deras Mudik Village, Gunung Kerinci District, Kerinci Regency. This type of research is cross sectional. The sample in this study was the number of patient visits, namely 212 respondents. Data were analyzed using Chi-Squere and Logistic Regression.

The results of the research show that there is a significant relationship between level of education, health status, family support and support from health cadres on the utilization of integrated development posts for non-communicable diseases (Posbindu PTM) in the Siulak Deras Community Health Center Working Area, Gunung Kerinci District, Kerinci Regency. There is no relationship between work and knowledge regarding the use of integrated development posts for non-communicable diseases (Posbindu PTM) in the working area of the Siulak Deras Community Health Center, Gunung Kerinci District, Kerinci Regency. The variables of health cadre support and family support are the most dominant variables in the utilization of integrated development posts for non-communicable diseases (Posbindu PTM) in the Siulak Deras Community Health Center Working Area, Gunung Kerinci District, Kerinci Regency

Analysis Of Organizational Factors And Organizational Structural Characteristics In The Implementation Of Clinical Risk Management At Raden Hospital Mattaher Jambi

Aliyardi - — 2025-03-26

This research is a combination research (mixed method). The combined research method is a combination of quantitative and qualitative methods to determine the analysis of the implementation of clinical risk management and influencing factors at Raden Mattaher Regional Hospital, Jambi. Qualitative data analysis is inductive, The results of the research show that the respondents' perception of the condition of the work unit in supporting a safety culture is that the majority responded positively, namely 75.23%, the respondents' perception of superiors in the work unit in supporting the safety culture, the majority responded positively, namely 82.55%, The respondents' perception Regarding communication in work units in supporting safety culture, the majority responded positively, namely 66.73%. Respondents' perceptions of the frequency of incident reporting in work units in supporting safety culture were 53.16% of respondents who responded positively. The majority of respondents stated that they had never reported IKP, namely 69.8%. Respondents' perceptions of the work atmosphere in the work unit in supporting safety culture were 73.08% of respondents who responded positively. It is necessary to improve PMKP and Safety Culture education for staff and units through training and supervision of units

Analysis Of Determinant Factors Of Antenatal Care Service Utilization At Jujun Public Health Center, Keliling Danau District, Kerinci Regency

Elvi Basri — 2025-03-26

This study aims to analyze the determinant factors for the utilization of antenatal care services at the Jujun Community Health Center, Keliling Danau District, KerincI Regency. This type of research is cross sectional. The sample in this study was the number of patient visits, namely 134 respondents. Data were analyzed using Chi-Squere and Logistic Regression. The results of the study showed that there was a significant relationship between age, occupation, knowledge, accessibility, history of illness, family support and level of satisfaction with the use of antenatal care services at the Jujun Community Health Center, Keliling Danau District, Kerinci Regency. There is no significant relationship between education and income and the use of antenatal care services at the Jujun Community Health Center, Keliling Danau District, Kerinci Regency. The most dominant determinant factors related to the use of Antenatal Care Services are the age variable with a p-value of 0.000, the knowledge variable with a p- value of 0.000 and the accessibility variable with a p-value of 0.000

Analysis Of Posyandu Cadre Performance Towards Elderly Satisfaction At Posyandu Elderly Siulak Gedang Community Health Center, Siulak District, Kerinci Regency

Widia Junita — 2025-03-26

Based on the initial survey conducted by researchers, the Siulak Gedang Health Center has the most villages, namely 26 villages in Kerinci Regency. In each village there are 5 Posyandu cadres, so the number of cadres at the Siulak Gedang Community Health Center is 130 people. However, monthly Posyandu visits do not reach the target because one of the reasons is that the Posyandu cadres are less active.

This study aims to analyze the performance of Posyandu Cadres on Elderly Satisfaction at the Elderly Posyandu, Siulak Gedang Health Center, Siulak District, Kerinci Regency. This type of research is cross sectional. The sample in this study was the number of patient visits, namely 142 respondents. Data were analyzed using Chi-Squere and Logistic Regression.

Based on the results of the multivariate logistic regression test on 2 variables related to elderly satisfaction, it was found that the most dominant variable was the service variable with a p-value of 0.000 and an odds ratio of 43,160, which means that poor performance of posyandu cadres has a risk of unsatisfied posyandu service satisfaction 43 times greater than with respondents who said the performance of posyandu cadres was good.

ANALYSIS OF ACCOUNTABILITY AND TRANSPARENCY OF HEALTH OPERATIONAL ASSISTANCE (BOK) PROGRAM IN IMPROVING THE EFFECTIVENESS OF COMMUNITY HEALTH CENTERS GUNUNG DISTRICT COMMUNITY SEVEN DISTRICTS OF KERINCI

Desfizar Wira — 2025-03-26

Health Operational Assistance (BOK) is a form of significant improvement in health services from the Minister of Health of the Republic of Indonesia in to help local governments achieve national targets in the health sector by issuing a program called Health Operational Assistance. This research aims to determine the accountability and transparency of the management of health operational assistance funds at the Pelompek Community Health Center, Kerinci Regency and, to determine the effectiveness of providing health operational assistance funds at the Pelompek Community Health Center, Kerinci Regency. The analytical method used is descriptive qualitative.

Based on the research results, it can be concluded that the Pelompek Community Health Center, Kerinci Regency has carried out accountability well and the health operational assistance program is quite transparent. This can be seen from the MINLOK and POA preparation system which involves all community health center staff as well as village community coordination meetings, and the implementation of the operational assistance program. Health care at the Pelompek Community Health Center, Kerinci Regency, can be said to have been running successfully.

ANALYSIS OF SMOKING BEHAVIOR FACTORS WITH THE INCIDENCE OF PULMONARY TB AT NURDIN HAMZAH HOSPITAL EAST TANJUNG JABUNG

Alvendra Fikri Prayumi — 2025-03-26

The prevalence of BTA Positive Pulmonary TB in Indonesia is 257 per 100,000 population aged >15 years. In 2022, East Tanjung Jabung Regency will contribute 483 cases of pulmonary TB. This research is an analytical study with a cross sectional design to determine the analysis of factors in smoking behavior and the incidence of pulmonary tuberculosis at the Nurdin Hamzah Hospital, East Tanjung Jabung Regency. Samples were taken using the Slovin formula. The sampling technique was purposive sampling with a total of 145 respondents. The results of the study showed that there was a relationship between smoking status, age when starting smoking, quantity of smoking, duration of smoking, type of smoking, gender, nutritional status (body mass index) and education on the incidence of pulmonary TB. There is no relationship between age and occupation on the incidence of pulmonary TB. Health workers are expected to further increase health promotion regarding the dangers of smoking and its relationship to Tuberculosis for individuals, families and groups/communities.

Evaluation Of Community-Based Total Sanitation Program Towards Open Defecation Free Village In The Working Area Of Muara Hemat Community Health Center, Batang Merangin District, Kerinci Regency

Ullfa Putri Syafniaty — 2025-03-26

This research was carried out with a cross-sectional design using a quantitative
descriptive approach. The sample size used for the STBM program facilitator population
was the total population, namely 4 people. The population of residents taken using
probability sampling, namely multistage random sampling, was 124 families. Data
collection techniques used were interviews, observation, and searching for secondary data
from the health service, subdistrict, and community health center. The STBM program in
the Muara Hemat Community Health Center Working Area, Batang Merangin District,
Kerinci Regency is included in the "less successful" category. The value of the
recapitulation of interview questionnaire data and observations of residents' latrine rooms
is 22.5. Meanwhile, based on the STBM program facilitator interview questionnaire, it is
with a score of 21. Variables that need to be improved include input, process, output, and
outcome variables. Suggestions that can be given to the government are to provide
support in developing appropriate technology for the STBM program. Suggestions to the
facilitators are to increase knowledge, assist residents, and make efforts to support each
other. Advice to residents is to get used to defecating only in healthy latrines, washing
hands with soap, and increasing hygiene efforts in latrines

Analysis Of Budget Refocusing Implementation On Program Achievements In The Service District Health Rabbit

Setrol Nadi — 2025-03-26

This research aims to analyze the implementation of budget refocusing on program
achievements at the Kerinci District Health Service. This research is a qualitative
descriptive study. The sampling technique is purposive sampling. Data collection used in
depth interview guidelines. The research was conducted at the Kerinci District Health
Service. Qualitative data analysis techniques are carried out by analyzing the context of
statements resulting from secondary data and primary data from an informant. The results
of this research show that there are details of the Special Non-Physical Allocation Fund
according to Province/Regency/City for Fiscal Year 2023 in Kerinci Regency, namely
IDR. 142,500,202. The Health Service programs that were affected by budget refocusing
were all implemented. According to the Regional Government Information System
(SIPD), there is a sequence, namely programs, activities, and sub-activities. All programs,
activities, and sub-activities, but some output achievements in budget realization are not
in accordance with what has been budgeted. For the Kerinci District Health Service to be
able to take more efficient and effective steps in efforts to allocate funds so that it does
not affect the achievements of programs, activities, and sub-activities that should be
implemented and the establishment of policies to improve economic conditions.

THE EFFECT OF GIVING SAMBILOTO LEAF EXTRACT (Andrographis paniculatu) ON PANCREATIC FUNCTION AND PANCREATIC HISTOPATHOLOGY IN WHITE MALE WISTAR RATS WITH DIABETES MELLITUS

Antony - — 2025-03-25

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels caused by impaired insulin secretion from pancreatic β cells.

This study aims to evaluate the effect of Andrographis paniculata leaf extract on pancreatic function and histopathological features of the pancreas of male Wistar white rats with diabetes mellitus. This study is an experimental study using a pre-post test control group design. The research sample of 24 Wistar rats was divided into 6 groups.

The results of observations conducted on all groups showed changes in amylase and lipase levels in the treatment group. The results of the normality test of amylase and lipase levels were said to be normally distributed because the p values were > 0.05, namely 0.100 and 0.436. Based on the differences in the average serum amylase levels, the researchers concluded that the treatment group given Andrographis paniculata leaf extract (Andrographis paniculata). dose of 600mg/KgBW had the highest decrease in serum amylase and lipase levels. Histopathology of pancreatic tissue showed that the treatment group given Andrographis paniculata leaf extract (Andrographis paniculata) dose of 600mg/KgBW) category score 1 because the number of degenerative cells with a degree of damage (<1-25%), the number of necrotic cells <25% and the number of inflammatory cells <10 in the entire pancreatic interstitial space experienced the most significant improvement. Sambiloto leaf extract (Andrographis paniculata) contains secondary metabolites in the form of saponins, tannins, flavonoids, and triterpenoids which help repair pancreatic cells damaged by diabetes mellitus.

The Effect Of Giving Cloves Extract (Syzygium Aromaticum) On Collagenization And Histopathological Picture Of Skin Tissue In The Healing Process Of Dermapenese Wounds In White Wistar Male Rats

Intan Azzahro — 2025-03-25

Clove is a native plant of Indonesia but is currently cultivated in several parts of the world including Brazil in the state of Bahia. This plant represents one of the richest sources of phenolic compounds such as eugenol, eugenol acetate and gallic acid and has great potential for pharmaceutical, cosmetic, food and agricultural applications. The antioxidant and antimicrobial activities of cloves are higher than those of fruits. This study was conducted to test and analyze the effectiveness of giving clove extract cream (Syzygium aromaticum) on collagenization and wound healing from dermapen in male white rats (Rattus norvegicus) of the Wistar strain. The sample in this study was male white rats (Rattus norvegicus) of the Wistar strain weighing 160 – 200 grams and aged 2 – 3 months. Determination of the sample using the Ferderer formula for 4 groups and the overall results were 24 rats which would be divided into 4 different groups. Phytochemical test results showed that clove extract (Syzygium aromaticum) contains secondary metabolite compounds, namely flavonoids, saponins, tannins, alkaloids, and steroids which have antioxidant, antimicrobial, and anti-inflammatory effects and play a role in the healing process of dermapen wounds and collagenization. Clove extract cream (Syzygium aromaticum) with a concentration of 12% is most effective in accelerating wound healing, namely in 12 days. The results of observations of histopathological images of skin tissue showed that treatment groups 1, 2, and 3 with the administration of clove extract cream (Syzygium aromaticum) with concentrations of 4%, 8%, and 12% had a collagen density of 75 – 100 compared to the control group <25%.

Antioxidant And Anti Aging Activity Test Of Salak Skin Extract Cream (Salacca Zalacca)

Betty Merdiani Putri — 2025-03-25

This study aims to see the antiaging activity of snake fruit skin extract (Salacca Zalacca) through the difference in collagen density between treatment groups 1, 2 and 3 with a concentration of snake fruit skin cream extract (Salacca Zalacca) of 10%, 20% and 30% and compare it with the control group without extract. This study is a True experimental study, with the selection of the type of research design used is Post Test Only Control Group Design, the methods used include phytochemical tests, antioxidant activity tests with the DPPH method, and observations of collagen density in the skin of mice exposed to UVB light. This study used test animals in the form of male white rats (Rattus norvegicus) Wistar strain weighing 150-250 gr. The test animals were divided into 4 groups. The results showed that snake fruit skin extract has strong antioxidant activity and can increase collagen density, so it has the potential as an active ingredient in anti-aging cosmetic products.

The Effect Of Giving Cloves Extract (Syzygium Aromaticum) On Liver Function And Liver Histopathology Picture Of Male Wistar White Rats Infected With Staphylococcus Aureus

Zulaikha Rizqina Rahmawati — 2025-03-26

This study was conducted to test and analyze the differences in histopathological features of liver tissue between the control group and the treatment group given clove extract (Syzygium aromaticum) with dose variations of 100mg/KgBW, 300mg/KgBW, and 500mg/KgBW. Clove extracts have many bioactivities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, and neuroprotective effects. The antioxidant activity of clove extract is due to the presence of phenolic compounds that can capture free radicals and reduce oxidative stress. The sample in this study was male white rats (Rattus norvegicus) Wistar strain weighing 160-200gr and aged 2-3 months. The results of phytochemical tests showed that clove extract contains secondary metabolites in the form of saponins, tannins, flavonoids, alkaloids, and steroids that help repair liver cells damaged by Staphylococcus aureus bacterial infection. The results of histopathological observations of liver tissue in treatment group 3, namely clove extract with a dose of 500 mg/kg BW, experienced the most significant improvement and approached the control group compared to the other groups

The Effect Of Giving Salak Skin Extract (Salacca Zalacca) On Hair Growth And Histopathological Picture Of Skin Tissue In The Healing Process Of Dermapen Wounds In White Rats Of Male Wistar Strain In Obesity Model

Laura Cintyadevi Widana — 2025-03-25

Vitamins, minerals, and antioxidants found in the skin of snake fruit (salacca zalacca) contribute to better hair health. The vitamins and minerals found in the skin can promote hair growth, improve hair quality, and reduce hair damage.The purpose of this study was to determine how snake fruit skin extract can accelerate the healing of wounds from dermapen and hair growth in obese Wistar white rats. This study used a quantitative experimental design research method with a post-test only group design.Treatment group 1 was given topical treatment with 5% salak skin extract cream given once a day for 21 days. Treatment group 2 Treatment group 2 mice were given topical treatment with 10% salak skin extract cream given once a day for 21 days. Treatment group 3 mice were given topical treatment with 15% salak skin extract cream given once a day for 21 days.. The results of this study, namely the extract of snake fruit skin, showed the presence of alkaloids and flavonoids that play a role in hair growth.With an average result of applying the cream extract in treatment group 3 which experienced the longest hair growth, namely 0.85 cm..So it can be assessed that the extract of snake fruit skin cream can accelerate the growth of hair follicles in male Wistar strain rats (Rattus norvegicus).

Antioxidant And Anti Aging Activity Test Of Cloves (Syzygium Aromaticum)

Alfa Roza — 2025-03-25

This study aimed to investigate the anti-aging effects of clove extract on collagen density and its antioxidant activity in mice exposed to UVB light..

This study is a True experimental study, with the selection of the type of research design used being Post Test Control Group Design, i used, with a control group and a treatment group given clove extract after UVB exposure.

The total number of test animal samples in this study was 24. The grouping of test animals was done randomly into 4 test groups and 6 animals in each group.

The results of this study concluded that the results of phytochemical analysis showed that clove extract contains flavonoids, saponins, alkaloids, steroids, and tannins, with flavonoids as the key to increasing collagen density. The antioxidant activity of clove extract is strong, with an IC50 value of 17.62 ppm included in the category of very strong antioxidants. Based on the significance test using One-Way ANOVA, it is known that the control group and the treatment group have significant differences in collagen density. The treatment group has a denser collagen density than the control group and the results of histopathological observations show that the control group produces collagen growth that is included in the thin category while the treatment group that was smeared with clove extract is included in the dense category. These results indicate that clove extract, with its high antioxidant capacity, can be a potential anti-aging agent by increasing collagen density.

The Effect Of Giving Salak Skin Extract (Salacca Zalacca) On Pancreatic Function And Pancreatic Histopathology Of Male Wistar Strain White Rats In Obesity Model

KKLP - — 2025-03-26

The most important function of the pancreas is to control the quality of blood sugar with the glycogen process. So that the percentage of sugar in the blood is accelerated by its release from the liver. And liver insulin is stimulated to convert glucose into glycogen and stored in cells, thereby reducing the percentage of sugar in the blood. Salak fruit skin extract contains secondary metabolites such as saponins, tannins, alkaloids, flavonoids, and steroids that help repair pancreatic cells damaged by obesity by stopping pancreatic cell apoptosis. Snake fruit skin has the potential to be a diabetes medicine because it has a mixed content. The type of research used is true experimental with post test only control group design. The results of histopathological observations of pancreatic tissue showed significant differences between the treatment and control groups. The treatment group with a dose of 600 mg/kgbb was different from the control group. Based on the results of the normality test, the significance results were 0.200 in all groups. Data is said to be normally distributed if the p value > 0.05

The Effect Of Giving Salak Skin Extract (Salacca Zalacca) On The Reduction Of Cholesterol Levels And Histopathology Of The Testis Of Wistar Male White Rats In An Obesity Model

Albert Prawira — 2025-03-26

This study aims to evaluate the effect of snake fruit skin extract (Salacca zalacca) on reducing cholesterol levels and histopathological features of testes in male Wistar strain white rats with obesity model. This study uses a quantitative experimental method with a true experiment design. Male Wistar rats (Rattus novergicus) were induced to eat high cholesterol in the form of quail egg yolk to increase body weight to obesity. The results showed that snake fruit skin extract with doses of 400 mg/KgBW and 600 mg/KgBW was effective in reducing total cholesterol levels in obese rats, with cholesterol levels less than 54 mg/dl. Histopathological observations of the testes showed improvements in testicular structure in the group given snake fruit skin extract, especially at a dose of 600 mg/KgBW which was close to normal conditions. The conclusion of this study is that snake fruit skin extract has the potential as a cholesterol – lowering agent and improves testicular function in obese rats. This study requires further research to perfect research for the development of herbal medicines based on snake fruit skin extract for the treatment of high cholesterol and reproductive disorders due to obesity.

The Effect Of Giving Clove (Syzygium Aromaticum) On Pancreatic Function And Pancreatic Histopathology Of Male Wistar White Rats Infected By Staphylococcus Aureus Bacteria

Agnes Oktania — 2025-03-26

Infection is still a health problem for developed and developing countries. The pancreas is one of the organs that often experiences infection. This study aims to analyze the effectiveness of giving clove extract (Syzygium aromaticum) on the pancreas function of male white rats (Rattus norvegicus) of the wistar strain infected with Staphylococcus aureus and how the histopathology is. The research sample was 24 male Wistar rats.

This study uses a quantitative experimental research type, namely by using a true experiment or laboratory experimental design. This study uses a post-test only control group design to determine and analyze the effects before and after administration of clove extract in improving pancreatic function in white rats (Rattus norvegicus) Wistar strain infected with Staphylococcus aureus bacteria. The results of the One-way Anova test on the results of observations of serum lipase and amylase levels showed a significance value of 0.000 or greater than 0.05. It was concluded that there was a significant difference between the control group, treatment group 1, treatment group 2, and treatment group 3. The Post Hoc LSD test showed that there was a significant difference between the control group and treatment group 1 (p = 0.000) and treatment group 2 (p = 0.000). There was no significant difference between the control group and treatment group 3 (p = 0.475). Clove extract contains secondary metabolites in the form of saponins, tannins, flavonoids, and triterpenoids that help repair damaged pancreatic cells due to Staphylococcus aureus infection. Administration of clove extract at a dose of 600 mg/kgBW is effective in improving pancreatic function in white rats (Rattus norvegicus) Wistar strain that experience Staphylococcus aureus infection. The results of histopathological observations of pancreatic tissue in treatment group 3 (600 mg/kgBW) experienced the most significant improvement and approached the control group (reference group) compared to other groups

The Effect Of Giving Cloves Extract (Syzygium Aromaticum) On Hair Growth And Histopathological Picture Of Skin Tissue In The Healing Process Of Dermapene Wounds In Wistar Strain White Rats

Calvin Connelly — 2025-03-26

Hair loss is a widespread concern and affects skin quality. Hair loss can occur due to many factors. Based on previous research, clove plants can overcome hair loss problems. This is because cloves can be used as extracts and contain secondary metabolites in the form of flavonoids, saponins, tannins, and steroids.

This study is a true experimental study, using a post-test only control group design. The sample in this study was 24 animals.

The results of the study concluded that administration of clove extract cream (Syzygium aromaticum) affected hair growth. Based on the difference in average hair length in the groups after testing. The conclusion of the research results stated that the greatest hair growth was in test group 3 which was given clove extract with a concentration of 12%. The group with the least hair growth was in the control group which was only given base cream. Administration of clove extract cream (Syzygium aromaticum) in the group after testing with concentrations of 3%, 9%, and 12% extra affected the healing process of dermapen wounds in white rats (Rattus norvegicus) Wistar strain. Based on phytochemical tests, it was shown that clove extract (Syzygium aromaticum) contains secondary metabolites in the form of flavonoids, saponins, tannins, and steroids. These compounds, especially flavonoids, help heal dermapen wounds and stimulate hair growth.

The Effect Of Giving Salak Skin Extract (Salacca Zalacca) On Collagenization And Histopathological Picture Of Skin Tissue In The Healing Process Of Dermapen Wounds In White Wistar Male Rats With Obesity Model

Tety Okta Prisca — 2025-03-26

Background This study aims to analyze the effect of snake fruit skin extract (Salacca zalacca) in accelerating the healing of dermapen wounds in obese Wistar white rats. The research method used a quantitative experimental design with a post-test only group design. The results of this study are that snake fruit skin extract contains active compounds such as alkaloids, flavonoids, saponins, and tannins which have anti-inflammatory and antioxidant effects. This observation was carried out with the aim of comparing wound healing between the group given the base cream and the group given snake fruit skin extract cream (Salacca zalacca) with 3 different concentrations, namely 10%, 15%, and 20%. This observation was carried out every day for 14 days. The treatment group showed an increase in the percentage of wound healing that was faster than the control group. The conclusion of this study is that snake fruit skin extract is effective in accelerating the healing of dermapen wounds in obese rats, with an increase in collagen fiber density at concentrations of 15% and 20%.

The Effect Of Giving Sambiloto Leaf Extract (Andrographis Paniculata) On Collagenization And Histopathological Picture Of Skin Tissue In The Healing Process Of Dermapen Wounds In White Wistar Male Rats

Ellen Aristika — 2025-03-26

This study aims to analyze and test the administration of d extractAndrographis paniculata (Andrographis paniculata) affect growth collagen in the wound healing process of dermapen scars in male Wistar white rats (Rattus norvegicus) and assessing its histopathological features. This study is a true experimental study, using a post-test only control group design. The sample in this study was 24 animals. Preparation of test animals is to increase the weight of mice and make dermapen wounds. Dermapen action is carried out with a needle depth of 2 mm and a wound width of 2 cm. The wound healing process is observed every day for 14 days. This study showed that the group given Andrographis paniculata leaf extract cream with concentrations of 5%, 7%, and 10% had an effect on the healing process of wounds from dermapen in obese white rats (Rattus norvegicus) wistar strain. The treatment group experienced total healing, while the control group given base cream did not. The results of histopathological observations showed that the control group produced very thin collagen growth, while in the treatment given Andrographis paniculata leaf extract with concentrations of 5%, 7%, and 10% the collagen was fully filled and dense. The results of phytochemical tests showed that Andrographis paniculata leaf extract contained secondary metabolites in the form of flavonoids, saponins, tannins, and triterpenoids. These findings indicate that Andrographis paniculata extract increases collagenization and accelerates wound healing, making it a promising treatment for wounds caused by dermapen.

The Effect Of Giving Sambiloto Leaf Extract (Andrographis Paniculatu) On Kidney Function And Kidney Histopathology Of Male Wistar White Rats With Diabetes Mellitus

Marcelia Soewito — 2025-03-26

Diabetes Mellitus is one of the threats to human health. The abnormalities that occur in the kidneys of people with diabetes mellitus begin with the presence of microalbuminuria. Microalbuminuria is generally defined as albumin excretion of more than 30 mg per day and is considered important for the onset of diabetic nephropathy which if uncontrolled will then develop into clinical proteinuria and end in kidney failure.

This study aims to prove the effect of leaf extract (Andrographis paniculata) on kidney function and histopathology of the kidneys of male Wistar rats with diabetes mellitus. This study is an experimental study using a pre-post test control group design. In this study, 24 male Wistar rats were used as samples which were divided into 6 groups and 4 rats for each group.

The results of the study showed that administration of leaf extract (Andrographis paniculata) at a dose of 600 mg/KgBW was effective in significantly improving kidney function in white rats (Rattus norvegicus) Wistar strain with diabetes mellitus. This improvement can be seen through the levels of urea, creatinine, and histological structure of the kidneys that have improved. Leaf extract (Andrographis paniculata) contains secondary metabolites in the form of saponins, tannins, flavonoids, alkaloids, and steroids that help repair kidney cells that experience fatty deposits and decreased kidney function due to diabetes mellitus. Given its antihyperglycemic and anti-inflammatory properties, Andrographis paniculata functions as a protective agent for kidney health in patients with diabetes mellitus.

The Effect Of Giving Sambiloto Leaf Extract (Andrographis Paniculata) On Reducing Cholesterol Levels And Histopathological Picture Of The Liver Of Male Wistar White Rats

Sabrina Sherly — 2025-03-26

Cholesterol is a lipophilic molecule that plays an important role in human life and does many things to help cells function properly.Cholesterol is needed by the body to build healthy body cells and produce hormones. However, the risk of heart disease and stroke increases with high cholesterol levels in the blood.

This study aims to prove, know and test the effect of administering sambiloto leaf extract.(Andrographis paniculata) on the decrease of cholesterol level and histopathology of liver of male white wistar rats. This research is an experimental research using pre-post test control group design. In this research, 24 male wistar rats were used as samples which were divided into 6 groups. Each group consists of 4 male wistar rats.

The results of the study showed that the extract of sambiloto leaves (Andrographis paniculata) proven effective in reducing cholesterol levels, body weight, andlow density lipoproteinswhite mouse (Rattus norvegicus) male Wistar strain fed with high fat feed. The results of phytochemical tests on sambiloto leaves (Andrographis Paniculata) conducted showed that there were secondary metabolite compounds in the extract of sambiloto leaves (Andrographis Paniculata) including flavonoids, alkaloids, saponins, steroidsand tannins. These compounds will eventually lower cholesterol levels,low density lipoproteinsand body weight in white mice (Rattus norvegicus) Wistar strain that has hypercholesterolemia.

The Effect of Pagoda Flower Extract (Clerodendrum Paniculatum) on Liver Function and Histopathological Features of the Liver of White Rat Strains Male Wistar Infected with Leptospira Interrogans Bacteria

Ellysa Gan — 2025-03-26

This study was conducted to test whether the effect of pagoda flower extract (Clerodendrum Paniculatum L.) on liver function and histopathological features of the liver of male Wistar white rats infected with leptospira interrogans bacteria. This study used 24 experimental animal samples divided into 4 groups, namely the control group, treatment (P1, P2, P3) with different treatments. The results of the phytochemical test of pagoda flower extract (Clerodendrum paniculatum L.) has secondary metabolite content such as alkaloids, flavonoids, saponins, and tannins. On the 14th day of observation, the treatment obtained significant results to restore normal SGPT liver function in treatment group 1 with a value 30.17 ± 2.9, treatment 2 with value25.17 ± 2.92, pass 3 with a value of 20 ± 2. SGOT levels became normal in treatment group 2 with values77.5±13.3 and treatment group 3 with a value of62.3 ± 11.4. The histopathology results with a score of 1 which states normal liver function is in treatment group 3 (P3) with a dose of 200mg/kgBB pagoda flower extract. The results of the data analysis have been normally distributed with p>0.05.

The Effect Of Giving Cloves Extract (Syzygium Aromaticum) On Kidney Function And Kidney Histopathology Of Male Wistar White Rats Infected With Staphylococcus Aureus Bacteria

Antonius Fransiskus Putra Meliala — 2025-03-25

This research aims toto test and analyze the effectiveness of administering clove extract (Syzygium aromaticum) on the kidney function of male white rats (Rattus norvegicus) of the Wistar strain infected with Staphylococcus aureus and how the histopathological picture is.The research sample, namely 24 male rats (Rattus norvegicus) of the Wistar strain were divided into 4 groups and received different treatments. The treatment group was given an infection with a suspension of Staphylococcus areus bacteria and clove extract (Syzygium aromaticum) with different doses of 150 mg/KgBW, 350 mg/KgBW, and 450 mg/KgBW. The results of the observation showed that clove extract contains secondary metabolites in the form of saponins, tannins, flavonoids, and steroids that help repair damaged kidney cells and decreased kidney function due to Staphylococcus aureus bacterial infection. The active compound that plays the most role in improving kidney function is flavonoids. Administration of clove extract at a dose of 450 mg/KgBW is effective in improving kidney function in white rats (Rattus norvegicus) of the Wistar strain infected with Staphylococcus aureus. This improvement can be seen through the levels of urea, creatinine, and the histological structure of the kidneys that have improved. The results of histopathological observations of kidney tissue in treatment group 3, namely clove extract with a dose of 450 mg/KgBW, experienced the most significant improvement and approached the control group compared to the other groups.

Synergistic Effects of Vitamin D3 and Vitamin E (α-tocopherol) on Haemoglobin Levels, Blood Glucose, and Neutrophil-Lymphocyte Ratio in Staphylococcus aureus Induced Septic Rats

Primta Bangun — 2025-03-25

This study examines the combined effects of Vitamin D3 and Vitamin E supplementation on haemoglobin levels, blood glucose, and the neutrophil-to-lymphocyte ratio in septic rats caused by Staphylococcus aureus. The rats were categorised into seven groups: Group 1: Control group; Group 2: Sepsis group; Group 3: DOX group (9 mg/kg); Group 4: DOX (9 mg/kg) combined with Vitamin D3 (36 IU/kg) and Vitamin E (250 mg/kg); Group 5: Vitamin D3 (36 IU/kg) and Vitamin E (250 mg/kg); Group 6: Vitamin D3 (72 IU/kg) and Vitamin E (250 mg/kg); Group 7: Vitamin D3 (144 IU/kg) and Vitamin E (250 mg/kg) were administered orally for one week. Blood samples were obtained to assess haemoglobin, glucose, and NLR levels. The research indicates that Staphylococcus aureus-induced sepsis markedly impacts haemoglobin levels and the neutrophil-to-lymphocyte ratio (NLR). Doxycycline, in conjunction with Vitamin D3 and Vitamin E, enhanced haemoglobin levels and decreased NLR. Nevertheless, no substantial variations in blood glucose levels were seen across the groups (p>0.05), although elevated doses of Vitamin D3 indicated some enhancement. The results indicate that the combination of Doxycycline with Vitamin D3 and Vitamin E may aid in the management of sepsis-related inflammation and the recovery of haemoglobin levels. Additional research is required to optimise dosage and therapy combinations.

The Effect Of Hydrogen-Rich Water Administration On Serum Glutathione (Gsh) Levels And Lung Histopathology In Male Wistar Rats Exposed To Cigarette Smoke

Zulaichah Zulaichah — 2025-03-25

Environmental factors such as exposure to cigarette smoke can result in decreased antioxidant concentrations, one of which is: glutathione(GSH). Water with a higher pH and hydrogen ion content than regular water is known as hydrogen-rich water (HRW). Also one of the functions of hydrogen ions is as an antioxidant. This study was conducted to see how the effect of hydrogen-rich water on serum GSH levels and histopathological changes in the lungs of male Wistar rats exposed to cigarette smoke for 28 days. This study used 20 rats in 4 groups, control group 1.2 and treatment group 1.2. In this study, hydrogen-rich water (HRW) was given and serum GSH levels were examined using the ELISA method. Then observations were made after the experimental animals were exposed to cigarette smoke, which was then examined for lung histopathology in rats. The results showed a significant difference in serum GSH levels in the four groups of rats with a p-value <0.001 supported by a large effect size (ES = 0.935) so it can be concluded that HRW intervention provides a large antioxidant effect through serum GSH levels in rats and lung histopathology results also showed no significant difference in the degree of inflammation K1, K2, KP1, and KP2 with a p-value = 0.599 and a small effect size (ES = 0.418)

Readiness Analysis Of Electronic Medical Record Implementation On Medical Record Completion Compliance In Inpatient Department Of RSIA Stella Maris Medan

Lidia Panggabean — 2025-03-25

Along with the development of information technology today, Electronic Medical Records (EMR) is a major advancement in health technology. Currently, Stella Maris Women and Child Hospital has started implementing Electronic Medical Records but not yet comprehensively. This study aims to identify the readiness of implementing Electronic Medical Records based on the HOT-Fit method. The type of research used is quantitative descriptive research. The data collection method was carried out using a questionnaire with a total sample of 163 respondents. Based on the research results obtained, each aspect has a positive influence on the net-benefit component with a significance value of 0.000 each (p<0.001). The highest Exp(B) value is owned by the Organization variable of 24.128, followed by Technology of 21.164, and Human of 17.452, so it can be indicated that the aspect that has the greatest influence on the dependent variable is the organizational variable. In its application, this organizational variable is the role of hospital management. Hospital management can provide support and encouragement to PPA to jointly implement and succeed in the implementation of Electronic Medical Records in hospitals. From the results obtained, it can be concluded that Stella Maris Women and Child Hospital is ready to implement Electronic Medical Records.

The Changes of Retinal Nerve Fiber Layer (RNFL) in Cataracts undergoing Phacoemulsification using Spectral Domain Optical Coherence Tomography

Nelly Christina Siahaan — 2025-03-25

Retinal nerve fiber layer (RNFL) is one of the vital layers of the retina with regard to the incidence and subsequent treatment of glaucoma. The damage done by glaucoma specifically involves this layer. Optical coherence tomography (OCT) is widely used by ophthalmologists for diagnosing and following retinal diseases such as diabetic retinopathy (DR), and OCT measurement of RNFL thickness is valuable for glaucoma screening and detection of progression. Cataract affects the measurement of retinal nerve fiber layer thickness as measured on OCT; and cataract surgery enhances the ability of OCT to measure the changes in retinal layers. We need to pay attention about the effects of phacoemulsification on RNFL thickness and its consequences to preserve the eye delicate tissues and structures and assure its functions and the knowledge will be beneficial for patients’ treatment in future.

Review: Anterior Segment Optical Coherence Tomography

Gusbakti Rusip — 2025-03-25

The cornea is a clear and transparent layer that covers the front surface of the eye, playing an important role in protecting the eye and allowing light to enter the eye for sight. As the layer that first receives light, the cornea also functions to refract the light so that it reaches the retina with the right focus, which is then translated by the brain into clear vision. Therefore, the health and integrity of the structures of the cornea are very important for the quality of a person's visual functions.

Role of SOD and GPx in Mitigating Oxidative Stress in Streptozotocin-Induced Diabetic Rats

Evelyn Angie — 2025-03-25

Diabetes mellitus is a chronic disease characterized by an increase in blood glucose levels, which leads to oxidative stress as a consequence. Streptozotocin works by damaging pancreatic beta cells, resulting in hyperglycemia. This chronic hyperglycemia can increase the production of free radicals. Moreover, streptozotocin can cause significant oxidative stress by damaging cellular DNA, lipids, and proteins. The excessive free radicals can deplete antioxidant reserves like SOD and GPx, as they are utilized to neutralize the free radicals. The aim of this study is to understand the role of SOD and GPx in reducing oxidative stress in streptozotocin-induced diabetic rats. Spectrophotometric analysis was utilized to quantify SOD and GPx levels in rat tissues, providing insights into the extent of oxidative damage. The results revealed that while the levels of SOD showed no significant difference after streptozotocin induction, but there was a noticeable decrease in SOD levels. In contrast, GPx levels decreased significantly following induction. In conclusion, this study underscores the relevance of monitoring SOD and GPx levels as biomarkers for assessing oxidative stress in diabetic conditions and guiding therapeutic interventions.

The Effect of Giving Tempeh Flour (Rhizopus oligosporus) on The Body Weight of Mice (Mus muscullus) on A Diet High in Saturated Fat

Rati harianti nindita putri — 2025-03-25

Obesity is caused by an imbalance between energy intake and expenditure, leading to the accumulation of excess fat. Obesity is increasing globally, and pharmacotherapy to treat it often has side effects and is difficult to access. Alternatively, traditional medicinal plants such as tempeh (Rhizopus oligosporus) are known to have efficacy in reducing obesity. The objective is to investigate the effect of tempeh flour on weight loss in mice fed a high saturated fat. Methods experimental study with pretest post-test controlled group design using male mice divided into 4 groups: regular, quail egg control, quail egg + drug control, and quail egg + tempeh flour control (2,4 grams/day/bb). Results: The group given tempeh flour showed better weight loss than the other groups. The group given orlistat also experienced weight loss. Conclusion Tempeh flour 2,4 grams/day/bb effectively reduces mice's body weight with a high saturated fat diet.

Effectiveness Of Red Betel Leaf (Piper crocatum) Decoction Water On Blood Glucose Levels Of Male Mice (Mus musculus) Diabetes Mellitus Model

Wiliam William — 2025-03-25

The incidence of Diabetes Mellitus in Indonesia has surged dramatically, rising from about 8.4 million people 1 2000 to an estimated 21.3 million by 2030. Antidiabetic drugs and insulin treatments frequently lead to side effects, highlighting the need for alternative therapies through traditional medicine. One promising option is the red betel plant (Piper crocatum), which contains chemical compounds such as flavonoids, alkaloids, and tannins that may help regulate blood glucose levels.

Effect of Fasting on Blood Glucose Levels

Selamat Ginting — 2025-03-25

Diabetes mellitus is a disease suffered by society. Disease This, If Not controlled with Good, can cause various dangerous complications for the body. One of the controls carried out is fasting. Fasting is holding back self. No eating and drinking, with reduced consumption of calories, mainly carbohydrates, is the purpose of the study. This is to know the influence of fast-to-level glucose in blood mice. Research methods This experiment is pure and has a time series design. The object study used galah-type male mice, as many as 36. The research was conducted from April to May 2023 at the Pharmacology Laboratory of the Deli Husada Deli Tua Health Institute. Bivariate data analysis using the One Way Anova statistical test with mark significance set p <0.05. The results showed a difference in the treatment of intermittent fasting diurnal 1 and 2 times a week with the group 3 and 6 times a week p = 0.000 ( p <0.05). At the same time, there was no significant difference (p> 0.05) between the groups given intermittent fasting treatment diurnal 3 times a week and 6 times a week. The importance of fasting in controlling blood sugar levels. Fasting done 3 times a week is more effective in lowering blood sugar levels than fasting 6 times a week.

The Role Of The Specular Microscopy In Endothelial Cell Changes Before And After Phacoemulsification

Deza Yumardika — 2025-03-25

Cataracts remain one of the leading treatable causes of blindness around the world. Phacoemulsification is the most frequently used technique for cataract extraction. The ultrasound (U/S) power needed for traditional or longitudinal phacoemulsification poses ongoing risks for endothelial cell loss and tissue damage. The examination of endothelial cells before phacoemulsification surgery is very important in determining the prognostic factors for visual acuity after cataract surgery. Specular microscopy is a non-invasive tool that is essential in ophthalmology, facilitating the evaluation of the corneal endothelium, a crucial aspect in eye health assessment and surgical planning. It provides detailed images that showcase the size, shape, density, and overall condition of the endothelial cells.

Evaluation of Hospital Management Information System (HMIS) Implementation Using HOT-Fit Method in Rasyida Kidney Special Hospital Medan

Sri Lestari Ramadhani Nasution — 2025-03-25

Implementation of HMIS in Rasyida Kidney Special Hospital Medan has been used since 2018 to support services in improvement, effectiveness, and work efficiency. However, there are problems such as unstable networks, sometimes errors when operating, and not being integrated directly with the BPJS system, resulting in delays in service from patient registration and data input to the patient discharge process. Evaluation is needed to measure successful implementation using the HOT-Fit (Human, Organization, and Technology Fit) method. The aim is to assess factors that positively influence HMIS's successful implementation by completing Google forms (56 respondents) and in-depth interviews (6 respondents). The mixed method is used with concurrent embedded strategy and PLS-SEM with SmartPLS v.4.1.0.6 to analyze. Results showed that user satisfaction has a 79.9% influence, showing that independent variables affect user satisfaction. The higher user satisfaction, the greater HMIS's use. Users have felt the ease of the system, despite an unstable network, frequent errors, and inadequate computer specifications. Increasing the bandwidth, initially 50mbps to 100mbps, so the network is stable, error problems can be overcome, and increasing computer specifications to run the application correctly if an update is necessary.

Comparative Analysis of TAM and HOT-Fit Methods in Evaluating SIMRS Implementation at Bhayangkara Hospital Medan

Sri Lestari Ramadhani Nasution — 2025-03-25

Background: Hospital Information System (SIMRS) is a system that includes data collection, data processing, information presentation, data analysis, and information inference needed to support various operational activities in the hospital.

Methods: The research used involved two approaches: outer model and inner model. The outer model was used to test validity and reliability with AVE, discriminant validity, Cronbach alpha, and composite reliabilities. The inner model was tested using R Square and hypothesis testing.

Results: The results of research based on the HOT-Fit method show that Human factors have a significant relationship to Benefits, Organization, and Technology. In addition, organizational factors also have a significant relationship with benefits and technology. Statistical tests show that Human -> Benefits, Human -> Organization, Human -> Technology, Organization -> Benefits, and Organization -> Technology (p-value = 0.000). Meanwhile, based on the TAM method, it shows that the usefulness factor has a significant relationship to Actual Use, Behavioral Interest, and Attitude. In addition, the Ease factor also has a significant relationship to Usability and Attitude. The Behavioral Interest factor has a significant relationship to Actual Use, and the Attitude factor has a significant relationship to Behavioral Interest. Statistical tests show Usability -> Actual Use, Usability -> Behavioral Interest, Usability -> Attitude, Convenience -> Usability, Convenience -> Attitude, Behavioral Interest -> Actual Use, and Attitude -> Behavioral Interest (p-value = 0.000).

Conclusion: The results of this study indicate that human and organizational factors have a significant effect on technology. In addition, Human factors affect Organization and Benefits, while Organization affects Benefits. Furthermore, usefulness affects attitude, usefulness, interest, and actual use, while convenience affects attitude and usefulness. Attitude affects Interest, and Interest affects Actual Use.

Diabetes Mellitus in the eyes of Cataract Patients Undergoing Phacoemulsification

Sindy Boru Sembiring — 2025-03-25

Cataract lenses are removed from inside the eye through the use of ultrasonic energy and an irrigation/aspiration process, which is then followed by intraocular lens implantation (IOL). The ultrasonic energy used to shave cataracts is currently so concentrated on the cataract itself, but it is still possible that this energy has a different effect on the eye tissue during the phacoemulsification process. Phacoemulsification in diabetic patients is quite challenging. We need to pay attention to these combined diseases and their consequences in order to preserve the delicate tissues and structures of the eye and ensure its function until the future.

Antioxidant and Anti-Aging Activity Test Pagoda Flower (Clerodendrum Paniculatum L)

Agita Agita — 2025-03-25

This study was conducted to test the antioxidant and anti-aging activity of pagoda flowers (Clerodendrum paniculatum L.). Antioxidant testing of pagoda flower extract through DPPH testing. Seeing the anti-aging activity of pagoda flower extract through differences in collagen density between the Control group without extract and treatment group 1 with 10% pagoda flower cream extract concentration, treatment 2 with 15% concentration, and treatment with 20% concentration of pagoda flower extract cream through DPPH testing obtained an IC50 value of 53.65 indicating strong antioxidant results. For the anti-aging activity of pagoda flower extract, the best collagen density area is group P3 and P2 because the collagen density is already very large and dense in the histopathological picture of skin tissue. The normality test uses Kolmogorov Smirnov with normally distributed data results p> 0.05. Then the homogeneity results using Levene's Test: the p-value is 0.675. So, the conclusion is that there is a significant difference in the average (mean) percentage of collagen density from the four groups.

Potential of consumption of red dragon fruit extract on mitochondrial cytochromes in the gastrocnemius muscle after strenuous exercise

Ade Indra Mukti — 2025-03-25

Background. Skeletal muscle activity with heavy intensity causes an increase in free radicals causing oxidative stress that causes damage to cell function to mitochondrial dysfunction and plays a role in the cytochrome regulation process as an induction of apoptosis which normally cannot be released from the mitochondria. This study aims to determine the antioxidant potential of red dragon fruit (RDF) to delay the occurrence of oxidative stress, which increases cell function in mitochondria in the gastrocnemius muscle. Methods. This study involved 25 three-month-old male rats with an average weight of 200 g. The RDF extract was obtained via ethanol extraction and concentrated using an air-drying method. Rats were randomly allocated into five groups as follows: two control groups (K1 [no-exercise, no RDF] and K2 [exercise, no RDF] and three test groups (P1, P2, and P3; subjected to exercise and treated with 75, 150, and 300 mg kg−1 body weight of RDF, respectively). The exercise was swimming for 20 min three times per week for 31 days. Cytochrome-C and MDA were measured via an enzyme-linked immunosorbent assay, and histopathological examinations were performed via hematoxylin and eosin staining of rat muscles. Results. Compared the MDA levels after the ingestion of RDF extracts were between the K2 group and the P1, P2, and P3 groups. The results showed significant differences (p <0.05 for P1 and P2, and p <0.01 for P3), indicating the production of free radicals the occurrence of oxidative stress and cytochrome-c (Identified as an essential mediator in the apoptotic pathway, unlocking mitochondrial cytochrome-c into an apoptotic pathway), Cytochrome-C levels were compared between the K2 (16.1 ng/mg protein) group and the P1(13.5 ng/mg protein), P2 (10.6 ng/mg protein), and P3 (7.2 ng/mg protein) groups. The results showed significant differences (p < 0.05 for P1 and P2, and p <0.01 for P3). with features of damaged muscle cells based on histopathology. Ingestion of the RDF extract improved gastrocnemius muscle cells, resulting in cell function repair. Conclusion. Red dragon fruit (antioxidant) in exercise suppresses oxidative stress on cytochrome-C so that apoptotic signals occur significantly in muscles, can prevent the apoptotic process, reduce tissue damage, cause repair of cell function, and mitochondria can work usually. If there is a lot of cytochrome in the cytosol, it indicates cell dysfunction

The Effect of Pagoda Flower Extract (Clerodendrum Paniculatum L.) on Pancreatic Function and Histopathological Features of the Pancreas of Male Wistar White Rats Infected with Leptospira Bacteria

Evalona Manurung — 2025-03-25

This study was conducted to test the effect of pagoda flower extract (Clerodendrum paniculatum L.) on pancreatic function and histopathological picture of the pancreas of male Wistar white rats infected with Leptospira interrogans bacteria. Based on the difference in the average lipase levels of treatment group 3, namely rats infected with bacteria and given pagoda flowers at a dose of 200mg/KgBW, had the greatest decrease in lipase levels and approached the control group. P3 group after being infected with bacteria amylase- lipase level 68.45U/L- 42.06U/L and after being given pagoda flower extract with a dose of 200mg/KgBB, the amylase-lipase level became 58.75U/L-22.71U/L. There was no necrosis for the histopathological picture of treatment group 3 (P3). However, there was still a little leukocyte infiltration in the pancreatic cells, so this treatment group got a score of 0 without necrosis of pancreatic cells. Thus, it can be concluded that pagoda flower extract affects the pancreatic function of rats infected with leptospira bacteria. The Kolmogorov-Smirnov data analysis p>0.05 is 0.200, so the data is usually distributed.

The Impact Of The Number Of Cigarettes And The Duration Of Smoking On The Bmi Of Students Of The Faculty Of Agriculture, Methodist University Of Indonesia In 2024

Gabriel Stevani Putri Ndruru — 2025-03-25

Background: Smoke is a major global health problem, causing more than 8 million deaths every 7 million years as a consequence of the use of tobacco directly and 1.3 million consequence exposure to cigarette smoke. In Indonesia, the prevalence of smokers aged 10-18 years increased from 7.2% (2013) to 9.1% (2018), making it the third country with the number of smokers the most. Global Youth Tobacco Survey data (2019) shows that 40.6% of students aged 13-15 years Once use tobacco, with 19.2% at the moment smoking. Body Mass Index (BMI) is used To evaluate relative weight to height. Based on Riskesdas 2018, in Indonesia 9.3% are underweight, 55.3% are typical, 13.6% are overweight, and 25.8% are obese.

Research purposes: To determine the impact of the number of cigarettes, duration of smoking, and BMI of students of the Faculty of Agriculture, Indonesian Methodist University, Medan based on the Brinkman index on students of the Faculty of Agriculture, University of Indonesia in 2024.

Research methods: This is a study of observational analytics with a design study using a cross-sectional study.

Research results: This study was primarily found in students consuming several cigarettes with <9 cigarettes/day, as many as 37 respondents (46.3%), then the duration of smoking was found in 51 respondents (63.7%) with a duration of smoking <10 years and Body Mass Index was found 28 respondents (35%) with a body mass index <18.5. There is a relationship between the number of cigarettes and Body Mass Index with a value of p = 0.045 (p0.05) and a relationship between the duration of smoking smoke and Index Mass Body with a p-value of 0.001 (p0.05). The factor with a more significant influence is the number of cigarette consumption with p-value = 0.013 and OR = 2.4.

Conclusion: There is a meaningful relationship between the number of cigarettes and the index mass body with a p-value = 0.045, and there is a long relationship between smoking and Body Mass Index with a p-value of 0.001

The Effect of Pagoda Flower Extract (Clerodendrum Paniculatum L) on Collagenization and Histopathological Features of Skin Tissue in the Healing Process of Dermapen Wounds in Male Wistar White Rats

Nabila Rizqiana Harsyah — 2025-03-25

This study was conducted to test the effect of pagoda flower extract (Clerodendrum Paniculatum L) on collagenization and histopathological features of skin tissue in the healing process of wounds from dermapen in male white Wistar rats. The treatment was given in the form of 10%, 15%, and 20% cream on the healing process of wounds from dermapen. Phytochemical tests found that pagoda flowers positively contained active compounds such as alkaloids, flavonoids, saponins, and tannins. From the observations of wound healing, the control group had 71.5% of wounds closed. In treatment group 1, the percentage of wound healing was 100% on the 13th day, and in treatment groups 2 and 3 on the 12th day. In histopathological observations, the collagen density of the wound was already tight in treatment groups 2 and 3, with 15% and 20% pagoda flower cream extracts. So, pagoda flower extract is effective in healing wounds from dermapen. Kolmogorov-Smirnov test normality test The results of wound healing data in each group are normally distributed with a significance value of 0.200> 0.05 in all test groups.

The Effect of Pagoda Flower Extract (Clerodendrum paniculatum) on Reducing Cholesterol Levels and Histopathological Features of the Liver of Male Wistar Strain White Rats with Obesity Model

Ignatius Jasen Hutomo — 2025-03-25

The study aimed to investigate the effects of pagoda flower extract (Clerodendrum paniculatum L) on reducing cholesterol levels and histopathological features of the liver of obese rats. This study used 24 white rats (Rattus norvegicus) Wistar strain into 4 groups, namely Control, Treatment 1, Treatment 2, and Treatment 3, with different doses. The results of the phytochemical test of pagoda flower extract contained secondary metabolites such as alkaloids, flavonoids, saponins, and tannins. This study was conducted with an initial stage of testing a high-fat diet for 14 days. The results showed that the rats got a Lee index value of 0.31 in treatment groups 1, 2, and 3. The study demonstrated that pagoda flower extract significantly reduced cholesterol levels and improved liver histopathology in obese rats, particularly at 150 mg/kg and 200 mg/kg. Microscopic images of the liver of mice in treatment group 3 given a dose of 200 mg/kg bb extract looked normal, no inflammation was seen, cells began to improve, and no necrosis and fatty deposits were seen. Data analysis using the Kolmogorov-Smirnov test The results of each group's data were normally distributed.

The Effect of Pagoda Flower Extract (Clerodendrum paniculatum) on Kidney Function and Histopathology of the Kidneys of Male Wistar White Rats Infected with Leptospira interrogans Bacteria

Sri Sinta — 2025-03-25

This study was conducted to test the effect of pagoda flower extract (Clerodendrum paniculatum. L) on reducing cholesterol levels and histopathological features of the liver of obese white Wistar rats. This study used 24 white Wistar rats divided into 4 groups, namely K, P1, P2, and P3, with different dosage treatments. The results of the phytochemical test of pagoda flower extract contained alkaloids, flavonoids, saponins, and tannins. This study was conducted with an initial stage of testing a high-fat diet for 14 days. The results showed that the rats obtained a Lee index value of 0.31 in treatment groups 1, 2, and 3. Based on the results obtained, there was a decrease in total cholesterol levels in rats. The group was given pagoda flower extract with a dose of 150 mg/kgbband 200 mg/kg bb no longer experienced high cholesterol levels because their cholesterol levels were <54mg/dl. Microscopic images of the liver of rats in group P3 with rats given a dose of 200 mg/kgbbpagoda flower extract looked normal, with no inflammation, necrosis, or fatty deposits. Data analysis using the Kolmogorov-Smirnov test The data results for each group were usually distributed.

Analysis Of Service Quality Towards Pregnant Women's Satisfaction Level At The Maternal And Child Health (Kia) Polyclinic, Pasar Masurai Community Health Center, Lembah Masurai District, Merangin Regency

Sondang Selviana Silitonga — 2025-03-25

Quality service has an impact on the performance of health workers such as pregnant women who undergo examinations, for example, maternal and baby health services which are the performance of midwives. This study aims to analyze the quality of service on the level of satisfaction of pregnant women at the maternal and child health (KIA) clinic, Pasar Masurai Health Center, Lembah Masurai District, Merangin Regency. This type of research is cross-sectional. The sample in this study was the number of patient visits, namely 100 respondents. Data were analyzed using Chi-Squere and Logistic Regression. The results of the research show that there is a significant relationship between tangible (physical evidence), reliability (reliability), responsiveness (responsiveness), assurance (guarantee), empathy (empathy) with the satisfaction of pregnant women at the maternal and child health polyclinic (KIA) Pasar Masurai Community Health Center Lembah Masurai District, Merangin Regency. After carrying out multiple logistic tests from 3 models, it was found that the most dominant factor influencing patient satisfaction was the tangible variable (physical evidence) with a p-value of 0.000, the reliability variable with a p-value of 0.001, and the empathy variable with p -value 0.000.

The Effect of Giving Salak Fruit Skin Extract (Salacca zalaca) on Liver Function and Histopathology of the Liver of Male Wistar White Rats with Diabetes Mellitus

Jessylyn Rusfardy — 2025-03-25

This study was conducted to test the effect of salak fruit skin extract (Salacca zalaca) on liver function and histopathological features of the liver of male white rats with diabetes mellitus. This study used 24 Wistar rats as experimental animals, divided into 4 groups, namely the control group and treatment (P1, P2, P3) with different treatments. The results of phytochemical testing of salak fruit skin extract contained secondary metabolites such as saponins, tannins, flavonoids, alkaloids, and steroids. On the 14th day of observation, the results showed that administering salak fruit skin extract (Salacca alpaca) at 600 mg/kg BW effectively improved liver function in white rats (Rattus norvegicus) with diabetes mellitus. This improvement can be seen through the SGOT and SGPT levels and the rat liver's histological structure, which is close to the expected results. The data analysis test on the normality test using Kolmogorov Smirnov showed that the significance results in the SGOT examination were 0.677> 0.05 and SGPT 0.551> 0.05, so the data was normally distributed. The homogeneity test results for the variables of group P0, group P1, P2, and P3 were homogeneous.

The Effects of Salak Fruit Skin Extract (Salacca Zalacca) on Kidney Function and Histopathology in Male Wistar Rats with Diabetes Mellitus

Maria Stefannie Soesanto — 2025-03-25

This study was conducted to determine the effect of Salak fruit skin extract (Salacca Zalacca) on kidney function and histopathology of the kidneys of rats with diabetes mellitus. This study used 20 white rats (Rattus norvegicus) into 5 groups, namely K-, K+, P1, P2 and P3 with different doses. The results of phytochemical testing of Salak fruit skin extract contain saponins, tannins, flavonoids, alkaloids, and steroids. The initial stage uses alloxan induction to induce diabetes mellitus in rats. The results After 14 days, the treatment groups (P1, P2 and P3) had experienced DM and were then given Salak fruit skin extract treatment of 200 mg/kgBW, 400 mg/kgBW, 600 mg/kgBW, and were seen to be normal in terms of urea and keratin levels. Based on the results of histopathology of the rat kidneys, which illustrated damage to the kidneys due to diabetes mellitus, it looked better and normal in treatments P2 and P3. data analysis In the One-Sample Kolmogorov Smirnov normality test, the significance results of Keratinin 0.079 > 0.05 and Ureum 0.109> 0.05 so that they are normally distributed.

Analysis Of Service Quality Towards Public Satisfaction Post Accreditation At Kemantan Public Health Center, Air Hangat Timut District Kerinci Regency

Subang Aini Nasution — 2025-03-25

Quality of service is the most important thing to pay attention to to achieve the goals of the service-providing agency. Based on surveys conducted by patients/families, patients are not satisfied with the physical appearance of the Puskesmas, for example, the appearance of the building and waiting room, the availability of parking, cleanliness, tidiness, and comfort of the room, as well as the equipment owned by the Puskesmas, many complain that the Puskesmas toilets are less comfortable and some damaged ceiling. This study aims to analyze the quality of health services and patient satisfaction at the Kemantan Community Health Center, Air Hangat Timur District, Kerinci Regency. This type of research is cross-sectional. The sample in this study was the number of patient visits, namely 100 respondents. Data were analyzed using Chi-Squere and Logistic Regression. The results of the research show that there is a significant relationship between tangible (physical evidence), reliability (reliability), responsiveness (responsiveness), assurance (guarantee), empathy (empathy) with patient satisfaction at the Kemantan Community Health Center, Air Hangat Timur District, Kerinci Regency. After carrying out multiple logistic tests from 3 models, it was found that the most dominant factor influencing patient satisfaction was the tangible variable (physical evidence) with a p-value of 0.000, the reliability variable with a p-value of 0.001, and the empathy variable with p -value 0.000.

The Influence of Performance and Organizational Commitment on Employee Job Satisfaction at Stella Maris Teluk Dalam Hospital

Anna Maria — 2025-03-25

As public service organizations, hospitals require good performance to improve the quality of service that will be provided to customers and satisfy customers. This study aims to determine the effect of performance and organizational commitment on employee job satisfaction at RSU Stella Maris Teluk Dalam. This type of research is quantitative in the form of an analytical survey with a cross-sectional approach. The sample of this study was 100 employees who work at the Stella Maris Bintang Laut Teluk Dalam General Hospital. The data were analyzed bivariate with the Spearman correlation test and multivariate with multiple linear regression tests. The results showed an effect of performance based on internal service quality, workload quantity, time, cost, supervision, and employee relationships (all value 0.000). In terms of organizational commitment, based on affective, normative, and ongoing commitment (all p-value 0.000) on employee job satisfaction. Multivariate analysis showed significant effects of time (p-value 0.004), supervision (p-value 0.029), and continuance commitment (p-value 0.000) on employee job satisfaction, with continuance commitment emerging as the strongest predictor. The conclusion is that performance and organizational commitment influence employee satisfaction, where the most influential variable is organizational commitment based on continuance commitment.

Analysis Of Health Service Quality With Patient Satisfaction In Siulak Mukai Community Health Center Siulak Mukai District, Kerinci Regency

Subang Aini Nasution — 2025-03-25

Quality of service is the most important thing to pay attention to to achieve the goals of the service provider agency. Based on a survey conducted by patients/patients' families, they were dissatisfied with the physical appearance of the Health Center, for example, the appearance of the building and waiting room, the availability of parking, cleanliness, tidiness, and comfort of the room, and equipment owned by the Health Center, many complained about the uncomfortable Health Center toilets and some damaged ceilings. This study aims to analyze the quality of health services and patient satisfaction at the Health Center. This type of research is cross-sectional. The sample in this study was the number of patient visits, which amounted to 100 respondents. Data were analyzed using Chi-Squere and Logistic Regression. The results showed a significant relationship between tangible (physical evidence), reliability, responsiveness, assurance, and empathy with patient satisfaction at the Siulak Mukai Health Center, Siulak Mukai District, Kerinci Regency. After conducting multiple logistic tests of 3 models, it was found that the most dominant factors influencing patient satisfaction were tangible variables (physical evidence) with a p-value of 0.000, reliability variables with a p-value of 0.001, and empathy variables with a p-value of 0.000.

Analysis Of Factors Influencing The Incidence Of Anemia In Pregnant Women At The Maternal And Child Health (Kia) Polyclinic, Pasar Masurai Community Health Center, Lembah Masurai District, Merangan Regency

Melani Susanti — 2025-03-25

The incidence of anemia can be caused by several factors, including age, parity, frequency of ANC visits, economic status, level of education, and compliance with consuming Fe tablets. This study aims to analyze the factors that influence the occurrence of anemia in pregnant women at the Maternal and Child Health Polyclinic at the Pasar Madurai Community Health Center, Merangin Regency. This type of research is cross-sectional. The sample in this study was the number of patient visits, namely 100 respondents. Data were analyzed using Chi-Squere and Logistic Regression. The results showed that there was a significant relationship between age, parity, ANC visits, and consumption of Fe tablets. There is no relationship between education level, economic level, and culture. After carrying out multiple logistic tests from 3 models, it was found that the most dominant factor influencing the incidence of anemia in pregnant women was the variable consumption of Fe tablets with a p-value of 0.000

Home Environmental Factors and ARI among Toddlers in Semurup Community Health Center, Kerinci Regency

Subang Aini Nasution — 2025-03-25

ARI is a disease that can cause death, especially in children. The initial survey that has been conducted still found that residents' houses are not permanent, some of which still use flammable materials such as wood and plywood. Semi-permanent houses are still quite a lot, namely 271, wooden houses as many as 68. The location of the house is close to the market, and there are still many houses that are close together. Some of the house ventilation there also still does not meet the requirements for a healthy home. This study aims to analyze the condition of the home environment with the incidence of ARI in toddlers in the Semurup Health Center Work Area, Air Hangat District, Kerinci Regency in 2023. This type of research is cross-sectional. The sample in this study amounted to 108 respondents. Data were analyzed using Chi-Squere and logistic regression. The results showed a significant relationship between parental knowledge, ventilation area, housing density, smoking habits, wall types, lighting, and air humidity with the incidence of ARI. There is no relationship between parental income and the incidence of ARI in toddlers. The variables of lighting, air humidity, and parental knowledge are the most dominant in the incidence of ARI in toddlers in the working area of the Semurup Health Center, Air Hangat District, Kerinci Regency in 2023.

Analysis Of The Implementation Of The Ispa Management Program In Toddlers In The Work Area Of Pelompek Community Health Center, Gunung Tujuh District, Kerinci Regency

Dewi Riastawaty — 2025-03-25

ISPA disease in Pelompek Health Center is included in the highest disease among other diseases with several cases of 507 visits. The results of the preliminary study conducted obtained data on the most sufferers by toddlers and conducted interviews with 10 mothers whose toddlers had experienced ISPA, namely 3 mothers said they only compressed their children with warm water and gave them warm water to drink without giving any medicine, 6 other mothers did not take any action when their children had a fever and cough, and 1 mother said she only gave her child medicine from the shop. This study is a mixed-methods study. This study uses a qualitative method that is descriptive in nature with primary data collection obtained through in-depth interviews about the ISPA control program with the person in charge of the ISPA program. This study is included in cross-sectional research because the data was collected at a certain time and was retrospective, with the sample being mothers of toddlers in the Pelompek Health Center work area with a total of 100 people. The results of the study showed that the role of the Pelompek Health Center in ten ISPA control programs for toddlers that ran optimally was only three programs, namely the availability of logistics, recording reporting, and network partnerships. In this case, the health center has limitations in running programs that cannot be run properly.

Tace To The Rescue: A Systematic Literature Review of Its Role in Battling Various Liver Metastases

Putu Patriawan — 2025-03-25

Liver metastasis, commonly originating from primary tumors such as colorectal, gastrointestinal, breast, and neuroendocrine malignancies, poses a significant treatment challenge. Patients with unresectable liver metastases are increasingly receiving transarterial chemotherapy (TACE) as a locoregional treatment. This systematic review evaluates the clinical outcomes, safety, and effectiveness of TACE in treating liver metastases across various cancer types. A systematic search of PubMed, PMC, and the Cochrane Library from January 2019 to December 2024 identified 848 articles. After removing 559 duplicates and excluding 167 abstracts, 122 full-text articles were assessed for eligibility. Exclusions included 30 case reports, 1 animal study, 3 non-English articles, 10 systematic reviews or meta-analyses, 2 pictorial reviews, 32 articles without available full text, 13 with no reported outcomes, and 2 retracted articles. The final analysis included 29 trials with 3,652 participants. Eight studies provided comparative data, while the rest were retrospective. The data suggest that TACE offers promising tumor control and may improve survival, but its effectiveness is influenced by factors like tumor burden, vascularization, and the underlying malignancy. Differences in treatment protocols, including chemotherapeutic agents and embolization materials, also affect outcomes. While TACE is generally well-tolerated, adverse effects such as liver function impairment and post-embolization syndrome have been observed. The review emphasizes the need for more randomized controlled trials and standardized treatment guidelines to better define TACE’s role in managing liver metastases.

The Effect of Family Functionality and Social Support on Hemodialysis Patient's Quality of Life Among CKD Patients with Hypertension and Diabetes in Royal Prima Hospital

Efratiwi Marpaung — 2025-03-25

Hemodialysis, which involves regular visits to the hospital, increases the risk of social disability, where lack of social support contributes to mental and emotional problems experienced by patients undergoing hemodialysis. This study aims to determine the effect of social support and family functionality on the quality of life of chronic kidney disease patients undergoing hemodialysis. This study involved 42 patients with chronic kidney disease undergoing hemodialysis at the Hemodialysis Unit of Royal Prima Medan Hospital, selected by incidental technique. Primary data in this study were collected using the Kidney Disease Quality of Life Questionnaire, Multidimensional Scale of Perceived Social Support, and Family APGAR, while secondary data were sourced from patients' medical records. Data were analyzed using binomial logistic regression. This study found that 78.5% of respondents had hypertension, 40.5% had diabetes mellitus, and 31% had both. In addition, most respondents had low levels of social support (38.1%) but had highly functional families (47.6%). Logistic regression analysis found that social support was the only factor affecting the quality of life of chronic kidney disease patients undergoing hemodialysis (p<0.001; OR: 13.355). It can be concluded that adequate social support benefits the quality of life of chronic kidney disease patients undergoing routine hemodialysis, so promoting a positive social environment that supports hemodialysis patients is necessary.