The Effect Of Giving Salak Skin Extract (Salacca Zalacca) On Collagenization And Histopathological Picture Of Skin Tissue In The Healing Process Of Dermapen Wounds In White Wistar Male Rats With Obesity Model

Abstract

Background This study aims to analyze the effect of snake fruit skin extract (Salacca zalacca) in accelerating the healing of dermapen wounds in obese Wistar white rats. The research method used a quantitative experimental design with a post-test only group design. The results of this study are that snake fruit skin extract contains active compounds such as alkaloids, flavonoids, saponins, and tannins which have anti-inflammatory and antioxidant effects. This observation was carried out with the aim of comparing wound healing between the group given the base cream and the group given snake fruit skin extract cream (Salacca zalacca) with 3 different concentrations, namely 10%, 15%, and 20%. This observation was carried out every day for 14 days. The treatment group showed an increase in the percentage of wound healing that was faster than the control group. The conclusion of this study is that snake fruit skin extract is effective in accelerating the healing of dermapen wounds in obese rats, with an increase in collagen fiber density at concentrations of 15% and 20%.