The Effect Of Giving Cloves Extract (Syzygium Aromaticum) On Liver Function And Liver Histopathology Picture Of Male Wistar White Rats Infected With Staphylococcus Aureus

Abstract

This study was conducted to test and analyze the differences in histopathological features of liver tissue between the control group and the treatment group given clove extract (Syzygium aromaticum) with dose variations of 100mg/KgBW, 300mg/KgBW, and 500mg/KgBW. Clove extracts have many bioactivities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, and neuroprotective effects. The antioxidant activity of clove extract is due to the presence of phenolic compounds that can capture free radicals and reduce oxidative stress. The sample in this study was male white rats (Rattus norvegicus) Wistar strain weighing 160-200gr and aged 2-3 months. The results of phytochemical tests showed that clove extract contains secondary metabolites in the form of saponins, tannins, flavonoids, alkaloids, and steroids that help repair liver cells damaged by Staphylococcus aureus bacterial infection. The results of histopathological observations of liver tissue in treatment group 3, namely clove extract with a dose of 500 mg/kg BW, experienced the most significant improvement and approached the control group compared to the other groups