The Effect Of Giving Salak Skin Extract (Salacca Zalacca) On Pancreatic Function And Pancreatic Histopathology Of Male Wistar Strain White Rats In Obesity Model

Abstract

The most important function of the pancreas is to control the quality of blood sugar with the glycogen process. So that the percentage of sugar in the blood is accelerated by its release from the liver. And liver insulin is stimulated to convert glucose into glycogen and stored in cells, thereby reducing the percentage of sugar in the blood. Salak fruit skin extract contains secondary metabolites such as saponins, tannins, alkaloids, flavonoids, and steroids that help repair pancreatic cells damaged by obesity by stopping pancreatic cell apoptosis. Snake fruit skin has the potential to be a diabetes medicine because it has a mixed content. The type of research used is true experimental with post test only control group design. The results of histopathological observations of pancreatic tissue showed significant differences between the treatment and control groups. The treatment group with a dose of 600 mg/kgbb was different from the control group. Based on the results of the normality test, the significance results were 0.200 in all groups. Data is said to be normally distributed if the p value > 0.05