The Effect Of Giving Salak Skin Extract (Salacca Zalacca) On The Reduction Of Cholesterol Levels And Histopathology Of The Testis Of Wistar Male White Rats In An Obesity Model

Abstract

This study aims to evaluate the effect of snake fruit skin extract (Salacca zalacca) on
reducing cholesterol levels and histopathological features of testes in male Wistar strain
white rats with obesity model. This study uses a quantitative experimental method with
a true experiment design. Male Wistar rats (Rattus novergicus) were induced to eat high
cholesterol in the form of quail egg yolk to increase body weight to obesity. The results
showed that snake fruit skin extract with doses of 400 mg/KgBW and 600 mg/KgBW
was effective in reducing total cholesterol levels in obese rats, with cholesterol levels less
than 54 mg/dl. Histopathological observations of the testes showed improvements in
testicular structure in the group given snake fruit skin extract, especially at a dose of 600
mg/KgBW which was close to normal conditions. The conclusion of this study is that
snake fruit skin extract has the potential as a cholesterol – lowering agent and improves
testicular function in obese rats. This study requires further research to perfect research
for the development of herbal medicines based on snake fruit skin extract for the
treatment of high cholesterol and reproductive disorders due to obesity.