The Effect of Giving Tempeh Flour (Rhizopus oligosporus) on The Body Weight of Mice (Mus muscullus) on A Diet High in Saturated Fat

Abstract

Obesity is caused by an imbalance between energy intake and expenditure, leading to the
accumulation of excess fat. Obesity is increasing globally, and pharmacotherapy to treat it
often has side effects and is difficult to access. Alternatively, traditional medicinal plants such
as tempeh (Rhizopus oligosporus) are known to have efficacy in reducing obesity. The
objective is to investigate the effect of tempeh flour on weight loss in mice fed a high
saturated fat. Methods experimental study with pretest post-test controlled group design using
male mice divided into 4 groups: regular, quail egg control, quail egg + drug control, and
quail egg + tempeh flour control (2,4 grams/day/bb). Results: The group given tempeh flour
showed better weight loss than the other groups. The group given orlistat also experienced
weight loss. Conclusion Tempeh flour 2,4 grams/day/bb effectively reduces mice's body
weight with a high saturated fat diet.