The Effect Of Giving Sambiloto Leaf Extract (Andrographis Paniculata) On Reducing Cholesterol Levels And Histopathological Picture Of The Liver Of Male Wistar White Rats

Abstract

Cholesterol is a lipophilic molecule that plays an important role in human life and does
many things to help cells function properly.Cholesterol is needed by the body to build
healthy body cells and produce hormones. However, the risk of heart disease and stroke
increases with high cholesterol levels in the blood.
This study aims to prove, know and test the effect of administering sambiloto leaf
extract.(Andrographis paniculata) on the decrease of cholesterol level and histopathology
of liver of male white wistar rats. This research is an experimental research using pre
post test control group design. In this research, 24 male wistar rats were used as samples
which were divided into 6 groups. Each group consists of 4 male wistar rats.
The results of the study showed that the extract of sambiloto leaves (Andrographis
paniculata) proven effective in reducing cholesterol levels, body weight, andlow density
lipoproteinswhite mouse (Rattus norvegicus) male Wistar strain fed with high fat feed.
The results of phytochemical tests on sambiloto leaves (Andrographis Paniculata)
conducted showed that there were secondary metabolite compounds in the extract of
sambiloto leaves (Andrographis Paniculata) including flavonoids, alkaloids, saponins,
steroidsand tannins. These compounds will eventually lower cholesterol levels,low
density lipoproteinsand body weight in white mice (Rattus norvegicus) Wistar strain that
has hypercholesterolemia.