The Effect of Pagoda Flower Extract (Clerodendrum paniculatum) on Kidney Function and Histopathology of the Kidneys of Male Wistar White Rats Infected with Leptospira interrogans Bacteria

Abstract

This study was conducted to test the effect of pagoda flower extract (Clerodendrum paniculatum. L) on reducing cholesterol levels and histopathological features of the liver of obese white Wistar rats. This study used 24 white Wistar rats divided into 4 groups, namely K, P1, P2, and P3, with different dosage treatments. The results of the phytochemical test of pagoda flower extract contained alkaloids, flavonoids, saponins, and tannins. This study was conducted with an initial stage of testing a high-fat diet for 14 days. The results showed that the rats obtained a Lee index value of 0.31 in treatment groups 1, 2, and 3. Based on the results obtained, there was a decrease in total cholesterol levels in rats. The group was given pagoda flower extract with a dose of 150 mg/kgbband 200 mg/kg bb no longer experienced high cholesterol levels because their cholesterol levels were <54mg/dl. Microscopic images of the liver of rats in group P3 with rats given a dose of 200 mg/kgbbpagoda flower extract looked normal, with no inflammation, necrosis, or fatty deposits. Data analysis using the Kolmogorov-Smirnov test The data results for each group were usually distributed.