The Effect of Pagoda Flower Extract (Clerodendrum Paniculatum) on Liver Function and Histopathological Features of the Liver of White Rat Strains Male Wistar Infected with Leptospira Interrogans Bacteria

Abstract

This study was conducted to test whether the effect of pagoda flower extract (Clerodendrum Paniculatum L.) on liver function and histopathological features of the liver of male Wistar white rats infected with leptospira interrogans bacteria. This study used 24 experimental animal samples divided into 4 groups, namely the control group, treatment (P1, P2, P3) with different treatments. The results of the phytochemical test of pagoda flower extract (Clerodendrum paniculatum L.) has secondary metabolite content such as alkaloids, flavonoids, saponins, and tannins. On the 14th day of observation, the treatment obtained significant results to restore normal SGPT liver function in treatment group 1 with a value 30.17 ± 2.9, treatment 2 with value25.17 ± 2.92, pass 3 with a value of 20 ± 2. SGOT levels became normal in treatment group 2 with values77.5±13.3 and treatment group 3 with a value of62.3 ± 11.4. The histopathology results with a score of 1 which states normal liver function is in treatment group 3 (P3) with a dose of 200mg/kgBB pagoda flower extract. The results of the data analysis have been normally distributed with p>0.05.