The Effects of Salak Fruit Skin Extract (Salacca Zalacca) on Kidney Function and Histopathology in Male Wistar Rats with Diabetes Mellitus

Abstract

This study was conducted to determine the effect of Salak fruit skin extract (Salacca Zalacca) on kidney function and histopathology of the kidneys of rats with diabetes mellitus. This study used 20 white rats (Rattus norvegicus) into 5 groups, namely K-, K+, P1, P2 and P3 with different doses. The results of phytochemical testing of Salak fruit skin extract contain saponins, tannins, flavonoids, alkaloids, and steroids. The initial stage uses alloxan induction to induce diabetes mellitus in rats. The results After 14 days, the treatment groups (P1, P2 and P3) had experienced DM and were then given Salak fruit skin extract treatment of 200 mg/kgBW, 400 mg/kgBW, 600 mg/kgBW, and were seen to be normal in terms of urea and keratin levels. Based on the results of histopathology of the rat kidneys, which illustrated damage to the kidneys due to diabetes mellitus, it looked better and normal in treatments P2 and P3. data analysis In the One-Sample Kolmogorov Smirnov normality test, the significance results of Keratinin 0.079 > 0.05 and Ureum 0.109> 0.05 so that they are normally distributed.