The Effect of Giving Salak Fruit Skin Extract (Salacca zalaca) on Liver Function and Histopathology of the Liver of Male Wistar White Rats with Diabetes Mellitus

Abstract

This study was conducted to test the effect of salak fruit skin extract (Salacca zalaca) on liver function and histopathological features of the liver of male white rats with diabetes mellitus. This study used 24 Wistar rats as experimental animals, divided into 4 groups, namely the control group and treatment (P1, P2, P3) with different treatments. The results of phytochemical testing of salak fruit skin extract contained secondary metabolites such as saponins, tannins, flavonoids, alkaloids, and steroids. On the 14th day of observation, the results showed that administering salak fruit skin extract (Salacca alpaca) at 600 mg/kg BW effectively improved liver function in white rats (Rattus norvegicus) with diabetes mellitus. This improvement can be seen through the SGOT and SGPT levels and the rat liver's histological structure, which is close to the expected results. The data analysis test on the normality test using Kolmogorov Smirnov showed that the significance results in the SGOT examination were 0.677> 0.05 and SGPT 0.551> 0.05, so the data was normally distributed. The homogeneity test results for the variables of group P0, group P1, P2, and P3 were homogeneous.