Neural Proloterapi

Authors

  • Edlin Edlin Departemen Anastesi, Fakultas Kedokteran, Kedokteran Gigi dan Ilmu Kesehatan Universitas Prima Indonesia
  • Nur Surya Wirawan Departemen Ilmu Anestesi Terapi Intensif dan Manajemen Nyeri, Fakultas Kedokteran Universitas Hasanuddin

DOI:

https://doi.org/10.34012/jpms.v4i2.3162

Keywords:

terapi nyeri, neural proloterapi

Abstract

Terapi nyeri dengan injeksi regeneratif merupakan terapi yang mulai berkembang dengan pesat dalam kurun waktu ini. Ilmu pengetahuan dasar dan penelitian klinis terbaru menunjukkan kalau injeksi larutan dekstrosa dapat mengurangi rasa sakit, meningkatkan fungsi keseluruhan dan mengembalikan fungsi jaringan ikat yang rusak kembali menjadi normal. Walaupun mekanisme aksi dekstrosa belum dipahami dengan baik pada tingkat sel, uji klinis telah melaporkan efek klinis positif dibandingkan dengan kontrol injeksi buta. Salah satu teknik regenerasi aktif injeksi yang mulai dilirik para peneliti adalah neural proloterapi (NP). Berbagai penelitian dan laporan kasus mulai bermunculan dan menunjukkan bahwa NP dapat dilakukan baik sebagai penanganan alternatif maupun penanganan utama dalam berbagai kasus penyakit dan berbagai kondisi yang disertai nyeri kronik. Keuntungan utama pendekatan teknik NP selain memerlukan biaya yang murah, tingkat keamanan yang tinggi dan kemudahan teknik juga dapat dipertimbangkan.

References

International Association of the Study of Pain. Pain Terms And Definitions [Internet]. 2022. Available from: https://www.iasp-pain.org/resources/terminology/

Dahlhamer J, Lucas J, Zelaya, C, Nahin R, Mackey S, DeBar L, et al. Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016. MMWR Morb Mortal Wkly Rep [Internet]. 2018 Sep 14;67(36):1001–6. Available from: http://www.cdc.gov/mmwr/volumes/67/wr/mm6736a2.htm?s_cid=mm6736a2_w

Scholl L, Seth P, Kariisa M, Wilson N, Baldwin G. Drug and Opioid-Involved Overdose Deaths — United States, 2013–2017. MMWR Morb Mortal Wkly Rep [Internet]. 2018 Dec 21;67(5152). Available from: http://www.cdc.gov/mmwr/volumes/67/wr/mm675152e1.htm?s_cid=mm675152e1_w

Reeves KD, Sit RWS, Rabago DP. Dextrose Prolotherapy. Phys Med Rehabil Clin N Am [Internet]. 2016 Nov;27(4):783–823. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1047965116300420

Lyftogt J. Pain conundrums: which hypothesis? Central nervous system sensitization versus peripheral nervous system autonomy. Australas Musculoskelet Med [Internet]. 2008 Nov;13(2). Available from: https://search.informit.org/doi/10.3316/informit.483439107098154

Wu Y-T, Ho T-Y, Chou Y-C, Ke M-J, Li T-Y, Tsai C-K, et al. Six-month Efficacy of Perineural Dextrose for Carpal Tunnel Syndrome. Mayo Clin Proc [Internet]. 2017 Aug;92(8):1179–89. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0025619617304068

Itkin A. Treatment of Trigeminal Neuralgia Utilizing Neural Prolotherapy: A Case Report. J Prolotherapy. 2016;8:961–5.

Geppetti P, Holzer P. Neurogenic inflammation. Boca Raton: CRC Press; 1996.

Reeves K, Lyftogt J. Prolotherapy: Regenerative injection therapy. In: Waldman S, editor. Pain Management. 2nd ed. Philadelphia: Elsevier; 2011.

Lyftogt J. Subcutaneous prolotherapy for Achilles tendinopathy: the best solution? Australas Musculoskelet Med. 2007;12(2).

Khandelwal A, Rath G. Neural Prolotherapy for Trigeminal Neuralgia. In: Rath G, editor. Handbook of Trigeminal Neuralgia. Singapore: Springer; 2019.

Conaway E, Browning B. Neural Prolotherapy for Neuralgia. J Prolotherapy. 2014;6:928–31.

Alawi K, Keeble J. The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation. Pharmacol Ther [Internet]. 2010 Feb;125(2):181–95. Available from: https://linkinghub.elsevier.com/retrieve/pii/S016372580900196X

Geppetti P, Nassini R, Materazzi S, Benemei S. The concept of neurogenic inflammation. BJU Int [Internet]. 2008 Mar;101(s3):2–6. Available from: https://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2008.07493.x

Rosen H. Minimally invasive Prolotherapy. In: Spring Training Seminar. Naples: The American Osteopathic Association Prolotherapy Integrative Pain Management; 2012.

Cui M, Honore P, Zhong C, Gauvin D, Mikusa J, Hernandez G, et al. TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists. J Neurosci [Internet]. 2006 Sep 13;26(37):9385–93. Available from: https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1246-06.2006

Lyftogt J. Subcutaneous prolotherapy for Achilles tendinopathy. Australas Musculoskelet Med. 2007;12(11):107–9.

Lyftogt J. Subcutaneous prolotherapy treatment of refractory knee, shoulder and lateral elbow pain. Australas Musculoskelet Med. 2007;12(2):110–2.

Lyftogt J. Prolotherapy for recalcitrant lumbago. Australas Musculoskelet Med. 2008;13(5):18–20.

Jimenez-Andrade JM, Mantyh WG, Bloom AP, Freeman KT, Ghilardi JR, Kuskowski MA, et al. The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain. Neurobiol Aging [Internet]. 2012 May;33(5):921–32. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0197458010003568

Maniquis-Smigel L, Dean Reeves K, Jeffrey Rosen H, Lyftogt J, Graham-Coleman C, Cheng A-L, et al. Short Term Analgesic Effects of 5% Dextrose Epidural Injections for Chronic Low Back Pain: A Randomized Controlled Trial. Anesthesiol Pain Med [Internet]. 2016 Dec 6;7(1). Available from: https://brief.land/aapm/articles/13520.html

Maniquis-Smigel L, Reeves KD, Rosen HJ, Lyftogt J, Graham-Coleman C, Cheng A-L, et al. Analgesic Effect and Potential Cumulative Benefit from Caudal Epidural D5W in Consecutive Participants with Chronic Low-Back and Buttock/Leg Pain. J Altern Complement Med [Internet]. 2018 Dec;24(12):1189–96. Available from: https://www.liebertpub.com/doi/10.1089/acm.2018.0085

Yelland MJ, Sweeting KR, Lyftogt JA, Ng SK, Scuffham PA, Evans KA. Prolotherapy injections and eccentric loading exercises for painful Achilles tendinosis: a randomised trial. Br J Sports Med [Internet]. 2011 Apr 1;45(5):421–8. Available from: https://bjsm.bmj.com/lookup/doi/10.1136/bjsm.2009.057968

Cheatham SW, Kolber MJ, Salamh PA. Meralgia paresthetica: a review of the literature. Int J Sports Phys Ther. 2013 Dec;8(6):883–93.

Abdel-Aziz AA, Al-Tamimy HM, Fahmy AM, Abd Allah MS. Assessment of Musculoskeletal Ultrasound Guided Injection of The New Regenerative Medicine Techniques (Neural Prolotherapy and Platelet Rich Plasma) Impact versus Well Established Techniques (Steroid Injection) in Cases of Carpal Tunnel Syndrome Secondary. Egypt J Hosp Med [Internet]. 2019 Jul 1;76(7):4514–23. Available from: https://ejhm.journals.ekb.eg/article_45034.html

Sallam RA, Abdelkhabir AA, Shabana AA. Comparative study between the effect of neural versus intra-articular dextrose prolotherapy on pain and disability in patients with knee osteoarthritis. Egypt Rheumatol Rehabil [Internet]. 2021 Dec 6;48(1):30. Available from: https://erar.springeropen.com/articles/10.1186/s43166-021-00079-w

Published

2022-11-28

How to Cite

Edlin, E., & Wirawan, N. S. (2022). Neural Proloterapi. Jurnal Prima Medika Sains, 4(2), 47-56. https://doi.org/10.34012/jpms.v4i2.3162