The Effect of Giving Tempeh Flour (Rhizopus oligosporus) on The Body Weight of Mice (Mus muscullus) on A Diet High in Saturated Fat

Abstract

Obesity is caused by an imbalance between energy intake and expenditure, leading to the accumulation of excess fat. Obesity is increasing globally, and pharmacotherapy to treat it often has side effects and is difficult to access. Alternatively, traditional medicinal plants such as tempeh (Rhizopus oligosporus) are known to have efficacy in reducing obesity. The objective is to investigate the effect of tempeh flour on weight loss in mice fed a high saturated fat. Methods experimental study with pretest post-test controlled group design using male mice divided into 4 groups: regular, quail egg control, quail egg + drug control, and quail egg + tempeh flour control (2,4 grams/day/bb). Results: The group given tempeh flour showed better weight loss than the other groups. The group given orlistat also experienced weight loss. Conclusion Tempeh flour 2,4 grams/day/bb effectively reduces mice's body weight with a high saturated fat diet.