The Effect Of Giving Sambiloto Leaf Extract (Andrographis Paniculata) On Reducing Cholesterol Levels And Histopathological Picture Of The Liver Of Male Wistar White Rats

Abstract

Cholesterol is a lipophilic molecule that plays an important role in human life and does many things to help cells function properly.Cholesterol is needed by the body to build healthy body cells and produce hormones. However, the risk of heart disease and stroke increases with high cholesterol levels in the blood.

This study aims to prove, know and test the effect of administering sambiloto leaf extract.(Andrographis paniculata) on the decrease of cholesterol level and histopathology of liver of male white wistar rats. This research is an experimental research using pre-post test control group design. In this research, 24 male wistar rats were used as samples which were divided into 6 groups. Each group consists of 4 male wistar rats.

The results of the study showed that the extract of sambiloto leaves (Andrographis paniculata) proven effective in reducing cholesterol levels, body weight, andlow density lipoproteinswhite mouse (Rattus norvegicus) male Wistar strain fed with high fat feed. The results of phytochemical tests on sambiloto leaves (Andrographis Paniculata) conducted showed that there were secondary metabolite compounds in the extract of sambiloto leaves (Andrographis Paniculata) including flavonoids, alkaloids, saponins, steroidsand tannins. These compounds will eventually lower cholesterol levels,low density lipoproteinsand body weight in white mice (Rattus norvegicus) Wistar strain that has hypercholesterolemia.