Mikroenkapsulasi atenolol dengan penyalut hidroksipropil metilselulosa (HPMC) menggunakan metode emulsifikasi penguapan pelarut
DOI:
https://doi.org/10.34012/jpms.v4i1.2261Keywords:
atenolol, HPMC, emulsifikasi penguapan pelarutAbstract
Tujuan utama dari penelitian ini adalah memformulasi mikroenkapsulasi atenolol dengan penyalut HPMC menggunakan metode emulsifikasi penguapan pelarut. Dalan metode ini, HPMC dilarutkan dalam pelarut campuran methanol-diklorometana. Sedangkan atenolol dilarutkan ke dalam larutan HPMC. Dalam gelas lain dimasukkan paraffin cair. Hasil penelitian menunjukkan rasio atenolol dan HPMC adalah 1:0,5; 1:1; dan 1:1,5 berturut-turut untuk masing-masing Formula (Formula I, II, III dan IV). Mikroenkapsulasi yang dihasilkan dievaluasi berdasarkan distribusi ukuran partikel dan senyawa aktif yang dilepaskan. Mikrokapsul memiliki distribusi ukuran partikel antara 212-2000 µm. Spektrofotmeter UV dalam metanol yang digunakan untuk mengukur konsentrasi senyawa aktif diperoleh 56,963 ± 17,589; 60,41 ± 1,0045; 60 dan 173 ± 1,0160 % untuk masing-masing Formula (Formula I, II, dan III). Dapat disimpulkan bahwa mikrokapsul dengan perbandingan atenolol dan HPMC 1:1,5 memiliki pelepasan zat aktif yang lebih baik. Kinetika atenolol yang dilepaskan dari mikrokapsul mengikuti persamaan Higuchi.
References
Gupta S, Swain RP, Subudhi BB, Bhattacharjee A. Formulation and evaluation of biphasic gastro floating tablets of nateglinide and atenolol. Biointerface Res Appl Chem. 2020;11(3):10906–22.
Nayak B. Evaluation of various HPMC grades on Microencapsulation Efficiency of Glimepiride. 2018 Jun 9;
Neswita E, Ben ES, Nofita R. Mikroenkapsulasi Atenolol Dengan Penyalut Albumin Menggunakan Metode Penguapan Pelarut. J Katalisator. 2018;3(1):19.
Jyothi NVN, Prasanna PM, Sakarkar SN, Prabha KS, Ramaiah PS, Srawan GY. Microencapsulation techniques, factors influencing encapsulation efficiency. Vol. 27, Journal of Microencapsulation. 2010. p. 187–97.
Aduri PR, Shaik US, Moodu M, Gaddam S, Anga M. Development and evaluation of sustained release microparticles of atenolol of gastrointestinal delivery. GSC Biol Pharm Sci. 2018;3(2):001–5.
Ahad HA, Haranath C, D RR, Gowthami M, V NJ, Sravanthi P. Overview on Recent Optimization Techniques in Gastro Retentive Microcapsules by Factorial Design. Int J Pharma Sci Res. 2019;10(9):247–54.
Enayati-Fard R, Akbari J, Saeedi M, Morteza-Semnani K, Morad H, Nokhodchi A. Preparation and characterization of atenolol microparticles developed by emulsification and solvent evaporation. Lat Am J Pharm. 2019;38(7):1342–9.
Upadhyay P, Upadhyay S. Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. J Appl Pharm Sci. 2011;1(6):186–90.
Sikdar KYK, Ahamed A, Alam MM, Sarkar MR, Sajeeb B. Formulation and In-vitro Evaluation of Bilayer Tablets of Atenolol and Amlodipine. Bangladesh Pharm J. 2019;22(2):153–69.
Chinwala M. Recent Formulation Advances and Therapeutic Usefulness of Orally Disintegrating Tablets (ODTs). Pharmacy. 2020;8(4):186.
Almadanti SA, Makmur I, Asra R, Umar S. Microencapsulation to Maintain The Activity and Stability of Drug Substances: A Review. Asian J Pharm Res Dev [Internet]. 2020;8(6):73–6. Available from: http://ajprd.com/index.php/journal/article/download/829/724
Zhang K, Zhuang Y, Zhang W, Guo Y, Liu X. Functionalized MoS2-nanoparticles for transdermal drug delivery of atenolol. Drug Deliv. 2020;27(1):909–16.
Clara S. ( 12 ) Patent Application Publication ( 10 ) Pub . No .: US 2020/0197313 A1. 2020.
Bonthagarala B. Formulation and Evaluation of Pulsatile Drug Delivery System of Atenolol,. Am J Biol Aand Pharm Res. 2014 Mar 1;volume 1:28–33.
Manivannan R, Jayalakshmi R. Formulation and in-vitro evaluation of captopril microspheres using different polymers. Int J Biol Pharm Res. 2017;8(3):112–6.
Tadwee I, Shahi S, Tribhuwan S, Gupta S, Vanamore S. Formulation Development & Evaluation of Spray Dried Nasal Mucodhesive Microspheres of Atenolol. Int J Pharm Res Allied Sci. 2011;1(1):34–40.
Saeed A, Adnan S, Farooq M, Masood Z, Mahmood A, Ranjha NM, et al. Development and optimization of atenolol loaded polymeric microspheres: In vitro attributes. Lat Am J Pharm. 2020;39(4):707–16.
Owayez AS, El-Ghany GMA, Hashim IIA. Potential use of polyvinyl acetate-polyvinylpyrrolidone mixture for the development of atenolol sustained release matrix tablets: Optimization of formulation through in Vitro-in Vivo assessment study. Chem Pharm Bull. 2017;65(6):545–57.
Gunda RK, Kumar JNS, Brahma CK, Satyanarayana V, Prashant KN. Design, formulation and evaluation of atenolol gastro retentive floating tablets. Asian J Pharm. 2015;9(4):S34–42.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Jurnal Prima Medika Sains
This work is licensed under a Creative Commons Attribution 4.0 International License.
