Effectiveness of Chia Seed (Salvia Hispanica) Extract Nano Emulsion Preparation on Alloxan-Induced Blood Sugar and Pancreas of Male Wistar Rats

Abstract

Type 2 Diabetes Mellitus is one of the most common metabolic disorders worldwide and its development is mainly caused by a combination of two main factors: imperfect insulin secretion by pancreatic β-cells. Serum amylase and lipase levels are used to diagnose pancreatic damage. This study was conducted to test and analyze the effectiveness of Chia seed (Salvia hispanica) extract nanoemulsion preparations on blood sugar and pancreas in male Wistar rats (Rattus norvegicus) induced by Alloxan. The sample of rats used was 25 in 5 groups (positive control, negative control, treatment 1, 2 and 3) where the extract preparation in the treatment was chia seed extract nanoemulsion with concentrations of 5%, 10% and 20%. With the results at a concentration of 20% also providing a decrease in amylase and lipase enzyme levels that were closer to the negative control group, indicating the potential for restoration of pancreatic function.