The impact of white turmeric rhizome extract on the histopathological characteristics of the pancreas in male wistar rats with diabetes

Abstract

This study investigates the potential of white turmeric (Curcuma zedoaria Rosc.) rhizome extract as a cost-effective treatment for managing diabetes, focusing on its impact on pancreatic histopathology and blood glucose levels in diabetic Wistar rats. The research employed a randomized pre-test and post-test control group design, with rats induced with alloxan to simulate diabetes. The treatment groups received varying doses of white turmeric extract (250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW) for 14 days. Histopathological analysis of the pancreas revealed that the white turmeric extract groups showed no signs of edema, inflammation, or necrosis, indicating a protective effect. Blood glucose level measurements demonstrated that the 500 mg/kg BW dose exhibited the most optimal results in lowering blood glucose levels. Statistical analysis using ANOVA and Kruskal-Wallis tests indicated significant differences between groups. These findings suggest that white turmeric extract, particularly at a dosage of 500 mg/kg BW, holds promise as a complementary treatment for managing diabetes by improving pancreatic health and reducing blood glucose levels. Further research is warranted to explore the underlying mechanisms and optimize its application.