PRIMER (Prima Medical Journal) <p>PRIMER (Prima Medical Journal) published the original peer-reviewed article of basic medical research and case reports. This journal is published twice a year (April and October).</p> en-US (Edy Fachrial) (Yonata Laia) Sat, 01 Apr 2023 00:00:00 +0000 OJS 60 LAPORAN KASUS SKIZOFRENIA PARANOID <p><em>Schizophrenia is a clinical syndrome of various psychopathologies involving cognition, emotion, perception, and other aspects of behavior. Schizophrenia is defined and diagnosed as a psychiatric disorder solely based on its clinical phenomenology. In this case, a 37-year-old man came with the main complaint of hearing disturbing whispers in his ear and believing that his family always talked about him. The patient is also suspicious of his parents and siblings, irritable, often alone, and unable to sleep. The patient also had auditory hallucinations, visions, and prominent delusions. The therapy given to patients was risperidone 2 x 1 mg orally / day and education for patients and their families. The patient's condition improved by showing a cooperative attitude that felt much calmer, and the patient never suspected his family and siblings again. Auditory hallucinations that appear can be controlled.</em></p> Adhayani Lubis Copyright (c) 2023 PRIMER (Prima Medical Journal) Sun, 30 Apr 2023 00:00:00 +0000 FORMULASI SEDIAAN HAIR TONIC EKSTRAK BIJI KETUMBAR (CORRIANDRUM SATIVUM L) SEBAGAI PENUMBUH RAMBUT PADA TIKUS PUTIH (Rattus Norvegicus) <p><em>Background: Coriander seeds (Coriandrum sativum L) contain linalool in them, causing antibacterial properties (Coriandrum sativum L.) (Hamudeng, 2017). Coriandrum sativum L, also known as a spice, is commonly used in Indonesia. It has various bioactive ingredients, including flavonoids, terpenoids, and polyphenols, which have medicinal effects. In addition, it is known that Coriandrum sativum has various pharmacological properties, including antioxidant, antidiabetic, and anti-dyslipidemia. (Irza, 2022). Purpose: To find out how to make hair tonic using coriander extract (corriandrum sativum L). To determine the characteristics of the physical properties and the pH of the tonic hair preparation of coriander seed extract. Methods: Experimental research will be used. Experiments were conducted to determine the best proportion of active ingredients from a mixture of coriander extracts to make hair tonic preparations. This experiment aims to produce tonic hair products that meet SNI. Materials: In this study, 15 white rats (Rattus norvegicus) were used as materials. Tools: PH meter. Results: Our hair tonic research showed that all preparations were stable for 28 days and stored at room temperature, and did not change color, smell, or texture. The results of the homogeneity test showed that there were no small grains during observation. Compared to formulas I and II, formula III produces the most stable preparation by producing less precipitate. Therefore, this is the best formula because F1 and F2 precipitate on the 21st day. However, the precipitate that can be redispersed is the precipitate resulting from the three formulas. Conclusion: Concentrations of coriander seeds 2.5%, 5.0%, and 7.5%, respectively, have a cloudy brown color, black-brown, and a distinctive aroma of coriander seeds which are weak, medium, and strong. They also meet the quality requirements of SNI 16-4955-1998 hair tonic, which is homogeneous and does not contain foreign particles. According to the pH test of Durante Hair Tonic, the average pH value is around 6.5, with a standard deviation of 0.10284. As a result of the pH values ‚Äč‚Äčobserved in this study, it can be concluded that this hair care product with coriander seed extract meets the standards.</em></p> <p><em> </em></p> Irza Haicha Pratama, Dewi Asri Sirait, Viona Masniari, Reshot Maria, Andre Budi Copyright (c) 2023 PRIMER (Prima Medical Journal) Sun, 30 Apr 2023 00:00:00 +0000 GAMBARAN KARAKTERISTIK PASIEN LIMFADENOPATIDI RUMAH SAKIT UMUM MADANI MEDAN TAHUN 2018-2019 <p>Lymphadenopathy's a disease in the form of inflammation of lymph glands caused by bacterial, viral, protozoan, rickettsia, or fungal infections. The purpose is to describe characteristics of lymphadenitis based on age, sex, gland location, and cytological diagnosis with lymphadenitis at Madani General Hospital Medan in 2018-2019. This research uses the retrospective descriptive method with a cross-sectional approach. Data were collected from medical records and then analyzed descriptively using the SPSS application. The results showed that there were 93 patients with lymphadenopathy. Patients with lymphadenopathy, mostly in adulthood, were 57 people (61.3%). Most patients with lymphadenopathy were female, 63 people (66.7%). The most common location was on the patient's right neck in 44 people (47.3%). The most common type was lymphadenitis in 53 cases (57%). Based on the relation between age characteristics and cytological diagnosis, most patients were adult patients diagnosed with lymphadenitis were 31 people. Based on the relation between sex characteristics and cytological diagnosis, the majority of patients were female with lymphadenitis, 53 people. Based on the relation between the characteristics of the location of lymph nodes and cytological diagnosis, the most common location of inflammation in the right neck of patients with lymphadenitis were 28 people.</p> Dicky Chandra Tafonao, Hermon Fanotona Marunduri, Evelyn Angie, Juliana Lina, Arie Siah Putra Siahaan Copyright (c) 2023 PRIMER (Prima Medical Journal) Sun, 30 Apr 2023 00:00:00 +0000 Uji Ekstrak Etanol Pakkat Terhadap Gambaran Histopatologi Pankreas Tikus Wistar Jantan Yang Diinduksi Aloksan <p>Objective: This take a look at ambitions to study the effectiveness of pakkat extract on the histopathological functions of the pancreas of male Wistar rats (Rattus novergicus) prompted with the aid of alloxan. methods: The layout used was an experimental layout with a pre-take a look at and publish-check randomized manipulate layout, the pattern used became 25 hyperglycemic rats divided into 5 groups: terrible manage (given NaCMC), high quality control (metformin), remedy 1 ( pakkat extract 125 mg/weight), remedy 2 (packkat extract 250 mg/ weight), treatment 3 (packkat extract 500 mg/weight) for 14 days. outcomes: The outcomes showed that pakkat extract (Calamus caesius blume) with tracking doses of one hundred twenty five mg/weight and 250 mg/weight for 14 days continuously ought to lessen the advent of alloxan-caused damage to the pancreas of male Wistar rats, which became characterized with the aid of reduced cellular look. infection, decreased interstitial bleeding, and reduced vascular congestion. conclusion: Pakkat extract (Calamus caesius blume) in positive doses can repair the harm to the structure of histopathological picture in male Wistar rats prompted via alloxan with the finest dose of 250 mg/weight.</p> Roland Daniel Theodore Amudi Matondang, Aleksander Marganda Sidebang, Yolanda Eliza Putri Lubis, Maya Sari Mutia, Stevenie - Copyright (c) 2023 PRIMER (Prima Medical Journal) Sun, 30 Apr 2023 00:00:00 +0000 Formulasi Dan Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Etanol Daun Kerai Payung (Fillicium Decifiens) Terhadap Bakteri Propionibacterium acne dan Staphylococcus epidermis <p><em>Sunshade (Fillicium decipiens) is a member of the Sapindaceae family, including some active antibacterial substances. To determine the antibacterial activity of Fillicium decipiens leaf ethanol extract gel against Propionibacterium acne and Staphylococcus epidermis bacteria, this study produced Fillicium decipiens leaf ethanol extract gel preparations using various extract concentrations and other formulations. Fillicium decipiens leaf extraction method by maceration using 96% ethanol. Prepare Fillicium decipiens leaf ethanol extract gel formulation using carbopol 940 base using various concentrations of Fillicium decipiens leaf ethanol extract, each 5%, 10%, and 15%. Gel preparations were tested for the physical properties of the gel, including an organoleptic test, pH test, homogeneity test, and spreadability test. As a result of organoleptic tests, the ethanol extract gel preparation of Fillicium decipiens leaves in each formula, namely F0 (clear color, extract aroma, semi-solid), F1 (greenish-brown color, extract aroma, semi-solid), F2 (greenish-brown color, extract aroma, semi-solid), F3 (greenish brown in color, parasol extract, relatively viscous), for the homogeneity test of the gel preparation formula, it was obtained entirely homogeneous. The formulation that produced the highest inhibition against Propionibacterium acne and Staphylococcus epidermis bacteria was formulation 3 (15% concentration of Fillicium decipiens leaf extract), where the inhibition zone obtained was 17.99 mm for Propionibacterium acne and 17.45 mm for Staphylococcus epidermis.</em></p> Gadis Minanda Fauziah Purba, Idaman Lase, Reh Malem br Karo, Razoki Lubis, Finna Piska Copyright (c) 2023 PRIMER (Prima Medical Journal) Sun, 30 Apr 2023 00:00:00 +0000